Elsevier

Comprehensive Psychiatry

Volume 16, Issue 6, November–December 1975, Pages 517-524
Comprehensive Psychiatry

Course of manic-depressive recurrences under lithium

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Cited by (17)

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    Kukopulos et al. (1975) first contrasted the cycle-sequence of depression preceding mania or hypomania followed by an illness-free interval (the DMI pattern), and its opposite (MDI) in bipolar disorder (BD) patients.

  • The primacy of mania: A reconsideration of mood disorders

    2009, European Psychiatry
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    Reversing this emphasis, we discuss the converse possibility – that mania can be seen as the core psychopathology of mood disorders, with depression its consequence. In Rome, one of us (AK) has led a group of clinicians that has published observational data about the course of bipolar disorder over four decades [79,81,83,87]. In this paper, we draw on that experience and on the psychopharmacology literature to re-examine the broad concept of mania as the prototype of nervous excitatory processes.

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