Case ReportImpact on bone microarchitecture and failure load in a patient with type I Gaucher disease who switched from Imiglucerase to Eliglustat
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Keywords
Gaucher disease
Bone disease
High-resolution peripheral quantitative computed tomography
Finite element analysis
Enzyme replacement therapy
Substrate replacement therapy
Abbreviations
GD
Gaucher Disease
GD1
Gaucher Disease (type I)
ICGG
International Collaborative Gaucher Group
DXA
Dual-energy x-ray absorptiometry
HR-pQCT
High-resolution peripheral quantitative computed tomography
MRI
Magnetic resonance imaging
BMD
Bone mineral density
ERT
Enzyme replacement therapy
SRT
Substrate reduction therapy
LS
Lumbar spine
FN
Femoral neck
LSC
Least significant change
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© 2020 The Authors. Published by Elsevier Inc.