Elsevier

Virology

Volume 384, Issue 2, 20 February 2009, Pages 335-344
Virology

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The human papillomavirus E7 oncoprotein

https://doi.org/10.1016/j.virol.2008.10.006Get rights and content
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Abstract

The human papillomavirus (HPV) E7 oncoprotein shares functional similarities with such proteins as adenovirus E1A and SV40 large tumor antigen. As one of only two viral proteins always expressed in HPV-associated cancers, E7 plays a central role in both the viral life cycle and carcinogenic transformation. In the HPV viral life cycle, E7 disrupts the intimate association between cellular differentiation and proliferation in normal epithelium, allowing for viral replication in cells that would no longer be in the dividing population. This function is directly reflected in the transforming activities of E7, including tumor initiation and induction of genomic instability.

Keywords

Human papillomavirus
E7 oncoprotein
Cellular transformation
Retinoblastoma tumor suppressor
p53
Genomic instability
Centrosome duplication
Ubiquitin ligase
Cell death
Cellular metabolism

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