Elsevier

Urology

Volume 79, Issue 1, January 2012, Pages 72-75
Urology

Female Urology
Metabolic Syndrome in Female Patients With Overactive Bladder

https://doi.org/10.1016/j.urology.2011.08.050Get rights and content

Objective

To investigate the relevance of metabolic syndrome in the etiopathogenesis of overactive bladder in female patients. It has been shown that obesity has been associated with overactive bladder (OAB), and the metabolic syndrome and insulin resistance have been related to the annual growth rates of prostate and lower urinary tract symptoms.

Methods

Female patients applying to our policlinics with OAB symptoms or other urologic complaints were enrolled in the study. The International Diabetes Federation criteria were used for the definition of the metabolic syndrome. The chi-square, Student t, and Mann-Whitney U tests and logistic regression analyses were used to compare differences in the variables.

Results

The metabolic syndrome was diagnosed in 201 (64%) of 313 patients with OAB and 73 (35%) of 208 patients without OAB. The difference was statistically significant (P = .002). A larger waist circumference, greater body mass index, low high-density lipoprotein level, and incidence of hypertension were significantly greater statistically in the OAB group than in the controls.

Conclusion

The metabolic syndrome correlates highly with OAB in female patients. The metabolic syndrome can be an etiologic pathway for the onset of symptoms.

Section snippets

Material and Methods

The present study was conducted prospectively in the public hospital of the University of Rize, Rize, Turkey. The subjects enrolled in the present study were aged 30-70 years. The female patients who applied to our policlinics with OAB symptoms or other urologic complaints were invited to participate in the present study from May 2009 to September 2010. The patients with symptoms from childhood or any congenital urologic abnormality were not included in our study. The patients with urinary

Results

A group of 313 patients with OAB in the study group and 208 age-matched controls without OAB were enrolled in the present study. The metabolic syndrome was diagnosed in 201 (64%) of 313 patients with OAB and 73 (35%) of 208 patients without OAB. The difference was statistically significant (P = .002). Compared with those without OAB, those with OAB were older (Table 1). No differences were found in marriage status, education level, smoking status, alcohol consumption, or incidence of

Comment

A growing number of studies have found relations between the metabolic syndrome and urologic disorders, including erectile dysfunction,13 benign prostatic hyperplasia (BPH), and LUTS.6, 7, 8 Initially, Hammarsten et al8, 9 found correlations among the annual prostate growth rates, metabolic syndrome, and fasting plasma insulin levels and concluded that BPH might be an insulin resistance-related disorder. This finding is supported by the study of Kaplan et al14 that a high correlation was found

Conclusions

The metabolic syndrome correlated highly with the OAB in female patients. The metabolic syndrome can be an etiologic pathway for the onset of symptoms, and avoiding a sedentary lifestyle and poor eating habits with weight loss or improvement in the treatment targeted toward the metabolic syndrome might be a worthwhile research area to develop into a potential therapeutic modality.

References (29)

  • V. Kupelian et al.

    Association of nocturia and mortality: results from the third National Health and Nutrition Examination Survey

    J Urol

    (2011)
  • W.F. Stewart et al.

    Prevalence and burden of overactive bladder in the United States

    World J Urol

    (2003)
  • K.G. Alberti et al.

    Metabolic syndrome—a new world-wide definition: a consensus statement from the International Diabetes Federation

    Diabet Med

    (2006)
  • M.P. Stern et al.

    Does the metabolic syndrome improve identification of individuals at risk of type 2 diabetes and/or cardiovascular disease?

    Diabetes Care

    (2004)
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