Female UrologyMetabolic Syndrome in Female Patients With Overactive Bladder
Section snippets
Material and Methods
The present study was conducted prospectively in the public hospital of the University of Rize, Rize, Turkey. The subjects enrolled in the present study were aged 30-70 years. The female patients who applied to our policlinics with OAB symptoms or other urologic complaints were invited to participate in the present study from May 2009 to September 2010. The patients with symptoms from childhood or any congenital urologic abnormality were not included in our study. The patients with urinary
Results
A group of 313 patients with OAB in the study group and 208 age-matched controls without OAB were enrolled in the present study. The metabolic syndrome was diagnosed in 201 (64%) of 313 patients with OAB and 73 (35%) of 208 patients without OAB. The difference was statistically significant (P = .002). Compared with those without OAB, those with OAB were older (Table 1). No differences were found in marriage status, education level, smoking status, alcohol consumption, or incidence of
Comment
A growing number of studies have found relations between the metabolic syndrome and urologic disorders, including erectile dysfunction,13 benign prostatic hyperplasia (BPH), and LUTS.6, 7, 8 Initially, Hammarsten et al8, 9 found correlations among the annual prostate growth rates, metabolic syndrome, and fasting plasma insulin levels and concluded that BPH might be an insulin resistance-related disorder. This finding is supported by the study of Kaplan et al14 that a high correlation was found
Conclusions
The metabolic syndrome correlated highly with the OAB in female patients. The metabolic syndrome can be an etiologic pathway for the onset of symptoms, and avoiding a sedentary lifestyle and poor eating habits with weight loss or improvement in the treatment targeted toward the metabolic syndrome might be a worthwhile research area to develop into a potential therapeutic modality.
References (29)
- et al.
The association of adiposity and overactive bladder appears to differ by gender: Results from the Boston Area Community Health Survey
J Urol
(2011) - et al.
Association of lower urinary tract symptoms and the metabolic syndrome: results from the Boston Area Community Health Survey
J Urol
(2009) - et al.
Bother related to bladder control and health care seeking behavior in adults in the United States
J Urol
(2009) - et al.
Translating overactive bladder questionnaires in 14 languages
Urology
(2006) - et al.
Prevalence of metabolic syndrome and its association with erectile dysfunction among urologic patients: metabolic backgrounds of erectile dysfunction
Urology
(2007) - et al.
Central obesity as measured by waist circumference is predictive of severity of lower urinary tract symptoms, sexual dysfunction, and components of the metabolic syndrome
J Urol
(2007) - et al.
Alterations of M2,3-muscarinic receptor protein and mRNA expression in the bladder of the fructose fed obese rat
J Urol
(2007) - et al.
Bladder dysfunction in rats with metabolic syndrome induced by long-term fructose feeding
J Urol
(2008) - et al.
Autonomic nervous system overactivity in men with lower urinary tract symptoms secondary to benign prostatic hyperplasia
J Urol
(2005) - et al.
Autonomic nervous system activity during bladder filling assessed by heart rate variability analysis in women with idiopathic overactive bladder syndrome or stress urinary incontinence
J Urol
(2007)