Frontiers in TransplantationLiver transplantationSevere Veno-occlusive Disease/Sinusoidal Obstruction Syndrome After Deceased-donor and Living-donor Liver Transplantation
Section snippets
Immunohistochemistry
Platelet activation and aggregation in the sinusoid space of Disse and parenchyma of the graft liver were evaluated by immunohistochemical staining for platelet surface receptor glycoprotein Ⅰ bα (GP Ⅰ bα: CD42b). The expressions of CD42b were examined immunohistochemically with respective primary antibodies using the EnVision+ System (DAKOk, Tokyo, Japan). De-waxed 4-μm sections were incubated with 1:50 with protein blocking serum for 10 minutes to block nonspecific binding; immunostaining was
Case 1
A 44-year-old woman underwent deceased-donor LT (DDLT) from an approximately 70-year-old donor with standard techniques including the piggyback technique (recipient middle and left hepatic two veins – graft inferior vena cava anastomosis) for end-stage liver disease because of autoimmune hepatitis. The patient's preoperative Model for End-stage Liver Disease (MELD) score was 29 points and the Child-Pugh score was 13 points with hepatic encephalopathy, massive ascites, and esophageal varices.
Discussion
Herein, we present two cases of VOD/SOS. The SOS was first described in a Jamaican child by Jelliffe et al in 1954 [19], replacing the previously named VOD. A considerable number of studies on VOD/SOS have since been conducted on recipients of hematopoietic stem cell transplantation. In the solid organ transplantation setting, SOS cases after kidney and liver transplantations were first reported as complications of azathioprine hepatotoxicity in 1982 [5] and 1991 [20], respectively. Only a few
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