Renal transplantationCandidateTuberculosis in Patients With End-Stage Renal Disease Undergoing Dialysis in an Endemic Region of Turkey
Section snippets
Materials and Methods
Adana in the southern part of Turkey is a district known for its influx of people from the inner country. We evaluated the data of 18 patients diagnosed with TB out of 343 patients on regular HD or CAPD between January 2001 and January 2006 at the Baskent University Faculty of Medicine, Adana, Turkey. We recorded the demographic characteristics; form of dialysis; date of initiation of dialysis; period of time between initiation of dialysis to diagnosis of TB; and the results from routine
Results
The clinical characteristics of our patients are shown in Table 1. TB was diagnosed in 18 of 343 patients (5.2%) undergoing dialysis. The patients underwent HD 3 days/week or CAPD 4 times/day.
Evaluation of the chest radiographs of 4 patients with pulmonary TB revealed apical infiltration in 3 and a cavitary lesion with infiltration in 1. Pleural effusion was present in 1 of the patients with infiltration. TB meningitis accompanied pulmonary TB in the patient with the cavitary lesion. Two
Discussion
ESRD patients are more susceptible to respiratory infections than are people in the general population owing to pathological changes in the airway and impairment of cellular immunity.9 Although some studies report that the incidence of TB does not increase in dialysis patients,10, 11 a recently published summary article reported that the incidence of TB is 6.9- to 52.5-fold greater in dialysis patients compared with the general population.1 Geographic, ethnic, and social factors may be reasons
References (21)
- et al.
Tuberculosis in patients with end-stage renal disease
Am J Med
(1980) - et al.
Respiratory infections and acute lung injury in systemic illness
Clin Chest Med
(1989) - et al.
Extrapulmonary involvement of mycobacterial infections in dialysis patients
Transplant Proc
(1999) Tuberculosis in patients on maintenance dialysis
Am J Kidney Dis
(1991)- et al.
Tuberculosis and chronic renal disease
Semin Dial
(2003) Increased incidence of tuberculosis in patients undergoing hemodialysis
Nephron
(1996)- et al.
Tuberculosis in active dialysis patients in Jeddah
Am J Nephrol
(1999) - et al.
Side-effects of antituberculosis drug treatment in patients with chronic renal failure
Eur Respir J
(2002) Global tuberculosis control: surveillance, planning, financing. WHO Report 2007
(2007)Trends in tuberculosis—United States, 2005
MMWR Morb Mortal Wkly Rep
(2006)
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Tuberculosis incidence in patients with chronic kidney disease: a systematic review and meta-analysis.
2022, International Journal of Infectious DiseasesCitation Excerpt :Furthermore, TB incidence among patients on peritoneal dialysis was reported in 18 studies, with a sample size ranging from 18 (Sen et al., 2008) to 25,704 (Klote et al., 2006). TB incidence in this group ranges from 310 per 100,00033 (Ahmed and Karter, 2004) to 22,220 per 100,000 (Sen et al., 2008). Among 35,086 patients on peritoneal dialysis, 509 developed TB, which gave a pooled estimate of 3533 per 100,000 (95%CI; 2220, 4846, I2; 86.29%) (Table 1, Figure 11).
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2015, TuberculosisCitation Excerpt :Three-hundred and twenty-one full text selections were further reviewed. However, many did not meet the study criteria due to the absence of measurable data on hepatotoxicity or failure to specify age-specific groups/events under comparison, leaving 38 studies for which we were able to obtain full datasets from the authors or article [7–44]. These included 40,034 participants with 1208 cases of hepatotoxicity, of which 339 occurred in those over the age of 60.
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2010, Side Effects of Drugs AnnualCitation Excerpt :There was chronic allograft dysfunction in 34 patients, 19 with graft loss. In a retrospective study in Turkey, tuberculosis occurred in 18 of 343 dialysis patients (39c). The mean time between the start of dialysis to the diagnosis of tuberculosis was 20 months.