Kidney transplantationComplication: Cardiovascular and metabolicRenal Osteodystrophy After Successful Renal Transplantation: A Histomorphometric Analysis in 57 Patients
Section snippets
Patients and Methods
This study was performed retrospectively on a cohort of 57 patients who underwent bone biopsy at various intervals after successful renal transplantation. The study was approved by the local university committee; patients provided informed consent. Indications for performing bone biopsy were as follows: persistent elevations of parathyroid hormone (PTH) levels in 12 cases; hypercalcemia in 7 cases; and 19 patients with second biopsy to detect transformation of ROD forms. In addition we included
Clinical Data and Laboratory Parameters
Available clinical data, including duration of dialysis prior to renal transplantation, interval between transplantation and bone biopsy, and cumulative prednisolone intake are shown in Table 2. Because the interval between bone biopsy and transplantation varied, there was a wide range of cumulative prednisolone doses. Highest doses of prednisolone were observed in patients with osteitis fibrosa and non–ROD. For patients with mild osteitis fibrosa and normal histological pattern, these
Discussion
This study was performed to investigate the histomorphometric forms of ROD after renal transplantation. Despite restoration of kidney function, patients developed various histological abnormalities. Our results agree with previous studies that demonstrated the variability of histological abnormalities of bone after transplantation.1, 2, 3, 4
In contrast to other organ transplant recipients patients with chronic renal failure develop ROD prior to kidney transplantation.13, 14, 15 Their form and
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