Renal transplantationOutcomeRenal Transplantation in Patients With Balkan Endemic Nephropathy
Section snippets
Patients and Methods
We retrospectively analyzed the database to identify renal transplant recipients who were diagnosed to suffer from BEN. These patients were followed prospectively. We reviewed the records of 601 renal transplant recipients who received organs between January 1995 and December 2004. Eighty-five percent of all patients received cadaveric transplant. From January 2006 to August 2006, four additional BEN patients received renal transplants; they were not included in investigation because of the
Results
Between January 1995 and December 2004, renal transplantation was performed in nine patients with BEN. The characteristics of the patients are shown in Table 1. There were three female and six male patients; age at transplantation ranged from 45 to 62 years. Number of HLA mismatches ranged from one to four. Delayed graft function occurred in two patients. One-year graft survival was 100%, with follow-ups ranging from 24 to 106 months.
Patient 1 was treated with hemodialysis for 79 months before
Discussion
Our results demonstrated that patients with BEN display an increased risk for development of UCC. These tumors are generally considered to be rare, but their incidence has increased in the population affected by BEN. The incidence of tumors was four- to 11-fold increased in the endemic area compared with the neighboring control area, and seven- to 60-fold increased when compared to distant nonendemic regions.4, 5, 6, 13, 14 In contrast, transplant recipients may development malignancies as a
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