Renal transplantation: complications: infectionsIntestinal perforation following renal transplantation: report of 2 cases related to cytomegalovirus disease☆
Section snippets
Case 1
In October 1995, a 33-year-old man received a renal transplant from his mother. Both the donor and recipient were positive for CMV antibodies. The immunosuppression was maintained with cyclosporine (CsA), azathioprine, and prednisone.
In August 2000, the recipient was readmitted with severe diarrhea and denutrition while receiving Mycophenolate Mofetil (MMF) and Prednisone; CsA had been stopped because of renal graft toxicity. The diagnosis of enteric CMV infection was made based on serologic
Discussion
The involvement of the gastrointestinal tract by CMV is reported in 2% to 16% of recipients of solid organ grafts. It generates multiple digestive symptoms that depend on the affected site. CMV colitis represents a serious localization of CMV disease and can lead to grave complications such as hemorrhage and perforation.3, 4 Its diagnosis is often difficult to establish due to nonspecific presenting symptoms and endoscopic features that are also observed in other pathological entities.
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Cited by (0)
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This study was supported by the Tunisian State—Secretariat for Research and Technology (Health Laboratory 02).