Original CommunicationPrognosis of patients undergoing hepatectomy for solitary hepatocellular carcinoma originating in the caudate lobe
Section snippets
Study population
Between 1988 and 2010, a total of 783 patients with solitary HCC underwent resection in the National Cancer Center Hospital, Tokyo. Patients with multiple HCCs found during preoperative imaging studies were excluded from the study, whether the HCCs represented intrahepatic metastases or multicentric occurrence. Included in the study were patients with macroscopically solitary HCC with intrahepatic metastases that could not be detected during preoperative imaging studies but were found during
Comparison of the resection outcomes of 46 patients with HCC in the caudate lobe and 737 patients with HCC in other sites in the liver
The background characteristics of patients with HCC in the caudate lobe and patients with HCC in other sites in the liver are shown in Table I. No significant difference in sex, hepatitis virus, hepatic function, laboratory data, and tumor markers were observed between the 2 groups. Operative and histopathologic parameters of all patients are shown in Table II.
Details of the operative procedures for HCC in the caudate lobe are summarized in Fig 1. The 46 patients underwent the following
Discussion
In the present study, no significant difference was observed in the background characteristics of patients who underwent hepatectomy for solitary HCC in the caudate lobe and in other sites. Hepatectomy for solitary HCC in the caudate lobe was more technically demanding than that for solitary HCC in other sites, a difference that was associated with greater operative times and blood loss, and lesser negative operative margins. Nevertheless, the 5-year overall and disease-free survival rates of
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Cited by (46)
A comprehensive study and extensive review of the Caudate lobe: The last piece of “Jigsaw” puzzle
2024, Asian Journal of SurgeryA systematic review and meta-analysis of caudate lobectomy for treatment of hilar cholangiocarcinoma
2020, European Journal of Surgical OncologyCitation Excerpt :The benefits of CLR in long-term survival need to be weight against potentially increased operating time and blood loss as well as perioperative morbidity and mortality [24,43,44]. In patients with liver cirrhosis or obstructive cholestasis with subsequent liver atrophy of the affected liver lobes, the caudate lobe is often associated with a significant hypertrophy and CLR could potentially result in a higher risk of posthepatectomy liver failure [45,46]. Unfortunately, a preoperative functional assessment of specific liver segments is currently not possible.
Stereotactic radiofrequency ablation of primary liver tumors in the caudate lobe
2020, HPBCitation Excerpt :Local recurrence rates and long-term survivals after SRFA of colorectal liver metastases,5 breast cancer liver metastases,21 intrahepatic cholangiocellular carcinomas,22 and melanoma liver metastases23 were comparable to resection. In the current study the 5-year overall survival rate (44%) after SRFA was comparable to hepatectomy (24%–54%; 66.7%–76%).9,24,25 According to recent studies surgical resection of caudate lobe HCC is associated with morbidity rates of 38–47%26–28 and mortality rates of 4.5%–14%.29
Anterior transhepatic approach for total caudate lobectomy including spigelian lobe, paracaval portion and caudate process: A Brazilian experience
2018, Hepatobiliary and Pancreatic Diseases InternationalSurvival outcomes after caudate lobectomy for hepatocellular carcinoma: systematic review and meta-analysis
2024, ANZ Journal of SurgeryThe successful posterior sectionectomy accompanied with caudate lobectomy for hepatocellular carcinoma located in segment 1 after LEN-TACE: a case report
2024, Clinical Journal of Gastroenterology
Supported in part by a grant-in-aid for scientific research from the Ministry of Health and Welfare of Japan.