VasculitisUtility of Erythrocyte Sedimentation Rate and C-Reactive Protein for the Diagnosis of Giant Cell Arteritis
Section snippets
Patients and Methods
The study was approved by the Mayo Clinic Institutional Review Board. Using the Mayo Clinic database, a data retrieval specialist identified all patients who underwent TAB at our institution between January 1, 2000 and December 31, 2008.
Results
A total of 1106 subjects underwent 1174 TAB at our institution between January 1, 2000 and December 31, 2008. TAB findings were consistent with GCA in 242 patients (21.9%).
Discussion
Biomarkers of inflammation, particularly the ESR and CRP, are often used in the evaluation of patients suspected of having GCA. However, performance of both in the diagnosis of GCA is not well described (5, 6). To our knowledge, the current study is the largest to date that evaluates these markers of inflammation in a cohort of patients undergoing TAB for the diagnosis of GCA. Additionally, we also assessed the frequency and clinical characteristics of patients with biopsy-positive GCA who had
Acknowledgments
Dr Kermani was supported by the Vasculitis Clinical Research Consortium (VCRC), which has received support from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54AR057319), the National Center for Research Resources (U54 RR019497), and the Office of Rare Diseases Research. The VCRC is part of the Rare Diseases Clinical Research Network (RDCRN).
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