InfectionPyogenic Vertebral Osteomyelitis: A Systematic Review of Clinical Characteristics
Section snippets
Literature Search
We collected the literature by searching the MEDLINE database starting with 1966. We also used textbooks of infectious diseases and orthopedics. The MEDLINE search string was “Discitis”[Mesh] OR “vertebral osteomyelitis” OR “spinal osteomyelitis” OR spondylodiscitis OR spondylitis NOT ankylosing NOT “case reports” [pt]. The results were limited to human studies published in the English language. Manual searches of reference lists from potentially relevant papers and book chapters were also
Study Characteristics and Limitations
Epidemiological, clinical, and microbiological aspects of PVO require careful interpretation for 2 reasons: (a) there is heterogeneity of the inclusion criteria among studies. Thus, 2 reports (10, 19) excluded drug abusers and 5 (10, 12, 16, 21, 23) excluded postoperative infections. On the contrary, in 1 report (14) intravenous drug abusers constituted the majority of the included patients. (b) Almost all the studies (93%) are retrospective, in which there is a potential for error because of
Discussion
We performed a systematic review of all PVO studies and identified 14 retrospective studies, including 1008 patients with PVO and excluding patients with tuberculosis and brucellosis. Based on these studies, we tried to clarify demographic, clinical, and microbiological characteristics of the disease, the contribution of various diagnostic procedures, and imaging studies to the etiological diagnosis of the disease, with particular attention to patient outcome.
PVO was found to affect mainly men
References (26)
Pyogenic vertebral osteomyelitis/disc infection
Bail Clin Rheum
(1999)- et al.
Spontaneous pyogenic vertebral osteomyelitis in nondrug users
Semin Arthritis Rheum
(2002) - et al.
Diagnosis and management of pyogenic vertebral osteomyelitis in adults
Surg Neurol
(1990) - et al.
Suggestions for managing pyogenic (non-tuberculous) discitis in adults
Joint Bone Spine
(2007) - et al.
Clinical features, diagnostic and therapeutic approaches to haematogenous vertebral osteomyelitis
Eur Rev Med Pharmacol Sci
(2005) - et al.
Spinal and spinal cord infection
Eur Radiol
(2004) - et al.
Management of vertebral diskitis and osteomyelitis
Orthopedics
(1999) - et al.
Hematogenous vertebral osteomyelitis due to Staphylococcus aureus in the adult: clinical features and therapeutic outcomes
South Med Assoc
(2005) - et al.
Bacteremic Staphylococcus aureus spondylitis
Arch Intern Med
(1998) - et al.
Pyogenic osteomyelitis of the spine in the elderly
J Neurosurg
(1991)
Vertebral osteomyelitis: an analysis of 38 surgically treated cases
Eur Spine J
The clinical use of magnetic resonance imaging in pyogenic vertebral osteomyelitis
Spine
Pyogenic, tuberculous, and brucellar vertebral osteomyelitis: a descriptive and comparative study of 219 cases
Ann Rheum Dis
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