Elsevier

Papillomavirus Research

Volume 1, December 2015, Pages 90-100
Papillomavirus Research

Estimation of the epidemiological burden of HPV-related anogenital cancers, precancerous lesions, and genital warts in women and men in Europe: Potential additional benefit of a nine-valent second generation HPV vaccine compared to first generation HPV vaccines

https://doi.org/10.1016/j.pvr.2015.06.003Get rights and content
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Abstract

Introduction

A second generation HPV vaccine has been developed for the prevention of anogenital cancers and precancerous lesions of the cervix, vulva, vagina, anus and of genital warts due to nine HPV types.

We estimated the annual burden of these diseases attributable to the nine HPV types compared to HPV types from first generation vaccines in women and men in Europe.

Material and methods

Incidence rates from the IARC database, cancer registries, the literature and Eurostat population data were used.

The burden attributable to the HPV types targeted by both vaccines was estimated by applying the relative contribution of the respective HPV types from epidemiological studies.

Results

In 2013, the number of new anogenital HPV-attributable cancers was 44,480 with 39,494 of these cases related to second vs. 33,285 to first generation vaccine types.

Among the 284,373 to 541,621 new HPV-attributable anogenital precancerous lesions 235,364–448,423 and 135,025–256,830 were estimated to be related to second and first generation vaccine types, respectively.

The annual number of new genital warts was 753,608–935,318, with 90% related to HPV6/11.

Conclusions

These data demonstrate how the large public health impact that was achieved by the first generation HPV vaccines could be further increased by second generation vaccines.

Abbreviations

AIN
anal intraepithelial neoplasia
CI
confidence interval
CI5
Cancer Incidence in Five Continents
CIN
cervical intraepithelial neoplasia
HPV
human papillomavirus
IARC
International Agency for Research on Cancer
VIN
vulvar intraepithelial neoplasia
VaIN
vaginal intraepithelial neoplasia

Keywords

HPV
Burden of disease
Cancer
Precancerous lesions
Genital warts
HPV vaccine

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