Original ArticleOutcomes of Unilateral Cataracts in Infants and Toddlers 7 to 24 Months of Age: Toddler Aphakia and Pseudophakia Study (TAPS)
Section snippets
Methods
This study was approved by the institutional review board or ethics review board at all participating institutions and complied with the Health Insurance Portability and Accountability Act. Data sharing agreements were established between the IATS investigator sites and the Mayo Clinic. All research adhered to the tenets of the Declaration of Helsinki.
Results
A total of 96 children (96 eyes) were registered through 10 IATS sites with a history of unilateral cataract surgery between 2004 and 2010. Two prior IATS clinical sites did not participate because of institutional review board limitations. Thirty eyes were excluded because of disqualifying baseline history or clinical findings, and 10 were not included because their follow-up ended before 4 years of age. Fifty-six children were eligible for review. Seven children in the TAPS registry were
Discussion
The low rate of complications, reoperations, and AEs after unilateral primary IOL implantation in older infants and toddlers (7–24 months of age at surgery) in this registry stands in striking contrast to that reported in IATS infants younger than 7 months at surgery. Despite the limits of retrospective data, the TAPS data are compelling because these procedures were performed through the care of IATS surgeons during the same period as the IATS.
In the early 2000s, a debate arose regarding the
References (36)
- et al.
Visual outcomes after surgery for unilateral cataract in children more than two years old: posterior chamber intraocular lens implantation versus contact lens correction of aphakia
J AAPOS
(1998) - et al.
Pediatric cataract surgery and intraocular lens implantation: practice styles and preferences of the 2001 ASCRS and AAPOS memberships
J Cataract Refract Surg
(2003) - et al.
5-year outcomes after primary intraocular lens implantation in children aged 2 years or younger with congenital or infantile cataract: findings from the IoLunder2 prospective inception cohort study
Lancet Child Adolesc Health
(2018) - et al.
Intraocular lens power calculation in children
Surv Ophthalmol
(2007) - et al.
Intraocular lens implantation during infancy: perceptions of parents and the American Association for Pediatric Ophthalmology and Strabismus members
J AAPOS
(2003) - et al.
Pediatric intraocular lens implantation: surgical results and complications in more than 300 patients
Ophthalmology
(1998) - et al.
A comparison of the rate of refractive growth in pediatric aphakic and pseudophakic eyes
Ophthalmology
(2000) - et al.
Refractive change in pediatric pseudophakia: 6-year follow-up
J Cataract Refract Surg
(2002) - et al.
Strabismus in pediatric pseudophakia
Ophthalmology
(2005) - et al.
Functional outcomes of acrylic intraocular lenses in pediatric cataract surgery
J Cataract Refract Surg
(2004)
Five-year postoperative outcomes of bilateral aphakia and pseudophakia in children up to 2 years of age: a randomized clinical trial
Am J Ophthalmol
Complications, adverse events, and additional intraocular surgery 1 year after cataract surgery in the Infant Aphakia Treatment Study
Ophthalmology
One-year strabismus outcomes in the Infant Aphakia Treatment Study
Ophthalmology
Strabismus surgery outcomes in the Infant Aphakia Treatment Study (IATS) at age 5 years
J AAPOS
Sensorimotor outcomes by age 5 years after monocular cataract surgery in the Infant Aphakia Treatment Study (IATS)
J AAPOS
The Infant Aphakia Treatment Study: evaluation of cataract morphology in eyes with monocular cataracts
J AAPOS
Infant Aphakia Treatment Study: effects of persistent fetal vasculature on outcome at 1 year of age
J AAPOS
Long-term risk of glaucoma after congenital cataract surgery
Am J Ophthalmol
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Supplemental material available at www.aaojournal.org.
Financial Disclosure(s): The author(s) have made the following disclosure(s): M.E.W.: Consultant – EyePoint Pharma; Royalties – Wolters Kluwer.
D.K.V.: Financial support – Retrophin, Inc.; Expert testimony – Franklin Casualty.
A.R.L.: Financial support – Knights Templar.
Supported by the Mayo Clinic, Rochester, Minnesota (CCaTS grant UL1TR000135). The sponsor or funding organization had no role in the design or conduct of this research.
HUMAN SUBJECTS: Human subjects were not included in this study. This retrospective chart review study was approved by the Institutional Review Board (IRB)/Ethics Review Board at all participating institutions (Mayo Clinic, Baylor College of Medicine and Texas Children’s Hospital, Cole Eye Institute, Duke University School of Medicine, Emory University School of Medicine, Harvard University, Indiana University, Medical University of South Carolina, Oregon Health and Science University, University of Minnesota, Vanderbilt University Medical Center) and complies with the Health Insurance Portability and Accountability Act. Data sharing agreements were established between the IATS investigator sites and the Mayo Clinic. All research adhered to the tenets of the Declaration of Helsinki. The written consent requirement was waived due to the retrospective nature of the study.
No animal subjects were included in this study.
Author Contributions:
Conception and design: Bothun, Wilson, Traboulsi, Diehl, Plager, Vanderveen, Freedman, Yen, Weil, Loh, Morrison, Anderson, Lambert
Analysis and interpretation: Bothun, Wilson, Traboulsi, Diehl, Plager, Vanderveen, Freedman, Yen, Weil, Loh, Morrison, Anderson, Lambert
Data collection: Bothun, Wilson, Traboulsi, Diehl, Plager, Vanderveen, Freedman, Yen, Weil, Loh, Morrison, Anderson, Lambert
Obtained funding: Bothun
Overall responsibility: Bothun, Wilson, Traboulsi, Diehl, Plager, Vanderveen, Freedman, Yen, Weil, Loh, Morrison, Anderson, Lambert
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Members of the Toddler Aphakia and Pseudophakia Study Group are available at www.aaojournal.org.