Original articleEfficacy of Intracameral Moxifloxacin Endophthalmitis Prophylaxis at Aravind Eye Hospital
Section snippets
Study Design
This is a retrospective, clinical registry–based study. The study protocol was conducted according to the principles described in the Declaration of Helsinki, and Institutional Review Board/Ethics Committee approval was obtained. The study population comprises all charity and private patients who underwent cataract surgery between February 15, 2014, and April 15, 2015, at the Madurai AEH. The charity population included patients who were transported to the base hospital for surgery from
Results
A total of 116 714 cataract procedures (including 12 601 bilateral cases) were performed from the February 15, 2014, to April 15, 2015, study period at the Madurai AEH. Of the 75 937 cataract surgeries performed in the charity population during this 14-month period, 37 777 (49.7%) did not receive IC moxifloxacin (group 1) and 38 160 (50.3%) did (group 2). There were 5364 and 4616 bilateral cases in groups 1 and 2, respectively.
Overall, 96.9% of the charity patients underwent M-SICS, and the
Discussion
Although phacoemulsification is the procedure of choice in developed countries, M-SICS is widely used in many developing world settings, where there is typically a large backlog of cataract blindness because of the lack of health care resources and ophthalmologists.17, 18 Compared with phacoemulsification, we and other groups have found M-SICS to be faster, more efficient, and more cost effective.22, 23, 24 Our large study at the Madurai AEH previously demonstrated that M-SICS is also safer
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Cited by (98)
The Effectiveness of Intracameral Moxifloxacin Endophthalmitis Prophylaxis for Trabeculectomy
2021, Ophthalmology GlaucomaCitation Excerpt :One recent in vitro study of 111 isolates of coagulase-negative Staphylococcus from clinical endophthalmitis specimens found that more than one third were resistant to ciprofloxacin and moxifloxacin.30 It has been posited that the high concentration of moxifloxacin in an intracameral injection improves its efficacy and minimizes this risk.4 We are not able to ascertain accurately whether intracameral moxifloxacin resulted in endophthalmitis organisms that were more resistant to treatment or susceptible to fewer antibiotics.
Letter to the Editor on “Antibiotic prophylaxis for cataract surgery – Practice patterns amongst Indian Ophthalmologists”
2024, Indian Journal of OphthalmologyChinese guideline for cataract surgery in adults (2023)
2023, Chinese Journal of OphthalmologySafety of intracameral application of moxifloxacin and dexamethasone (Vigadexa®) after phacoemulsification surgery
2023, Graefe's Archive for Clinical and Experimental Ophthalmology
See Editorial on page 226.
Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Author Contributions:
Conception and design: Haripriya, Chang, Ravindran
Data collection: Namburar, Smita
Analysis and interpretation: Haripriya, Namburar, Smita, Ravindran
Obtained funding: Not applicable
Overall responsibility: Haripriya, Chang