Original articleCollaborative Retrospective Macula Society Study of Photodynamic Therapy for Chronic Central Serous Chorioretinopathy
Section snippets
Methods
Macula Society members of the Research and Education Committee and the Website Committee collaborated with the Jaeb Center for Health Research to perform an investigator-reported retrospective, online study of outcomes after PDT in eyes with CSC. Macula Society members were invited to participate in an internet-based electronic survey. Patient demographic information, PDT treatment parameters, fluorescein angiographic information, optical coherence tomography (OCT) metrics, pre-treatment and
Results
Data were submitted on 237 patients with CSC from 11 countries and were submitted by 37 of 384 Macula Society members. By controlling for baseline VA, there was no effect of investigators on VA outcomes for investigators enrolling 10 or more eyes (P > 0.01). There were 110 patients from the United States, 47 patients from Italy, 17 patients each from Japan and the United Kingdom, 16 patients from Germany, 9 patients from Saudi Arabia, 6 patients each from Colombia and Northern Ireland, 4
Discussion
This retrospective investigator-reported study represents the largest collection of cases with chronic CSC treated with verteporfin PDT. In our study, PDT therapy resulted in improved VA, resolution of SRF (on both clinical examination and OCT), and reduction in fluorescein angiographic leakage in the majority of the treated eyes. There was no association between VA outcome and fluence setting, baseline ocular characteristics, gender, age, or lesion type. Adverse side effects were uncommon, and
References (23)
- et al.
Fundus autofluorescence and visual acuity in central serous chorioretinopathy
Ophthalmology
(2011) - et al.
Subfoveal choroidal thickness after treatment of central serous chorioretinopathy
Ophthalmology
(2010) - (2012)
- et al.
Long-term follow-up of a prospective trial of argon laser photocoagulation in the treatment of central serous retinopathy
Br J Ophthalmol
(1988) - et al.
Eight-year follow-up of central serous chorioretinopathy with and without laser treatment
Graefes Arch Clin Exp Ophthalmol
(1987) - et al.
Indocyanine green angiography-guided photodynamic therapy for treatment of chronic central serous chorioretinopathy: a pilot study
Retina
(2003) - et al.
Photodynamic therapy for chronic central serous chorioretinopathy
Retina
(2003) - et al.
Optical coherence tomography in unilateral resolved central serous chorioretinopathy
Retina
(2005) - et al.
High-resolution imaging of resolved central serous chorioretinopathy using adaptive optics scanning laser ophthalmoscopy
Ophthalmology
(2010) The Cambridge Dictionary of Statistics
(2006)
Photodynamic therapy of subfoveal choroidal neovascularization: clinical and angiographic examples
Graefes Arch Clin Exp Ophthalmol
Cited by (0)
∗Supplemental material is available at www.aaojournal.org.
Financial Disclosure(s): The author(s) have made the following disclosure(s): RFS receives royalty payments from Topcon.
Grant Support: Unrestricted educational grant from QLT to the Macula Society, Core Grant EY01792 (University of Illinois at Chicago), and an unrestricted grant from Research to Prevent Blindness.
- ∗
A list of members of the Macula Society CSC Collaborative Study Group, Research and Education Committee and Website Committee appear in Appendix 1 (www.aaojournal.org).