Original articleAn Evidence-Based Review of Prognostic Factors for Glaucomatous Visual Field Progression
Section snippets
Search Strategy
In September 2010, we conducted a systematic search in PubMed, EMBASE, and all databases and registers of The Cochrane Library using the following keywords: (glaucoma*) AND (prognos* OR predict* OR progress* OR longitudinal OR cohort OR follow-up) AND (perimetr* OR visual field* OR HFA [Humphrey Field Analyzer] OR Octopus OR Humphrey [not in author]). The search was limited to articles in English, Dutch, French, or German. Articles in press were also selected. In total, we identified 2733
Judgment Procedure
The 85 included studies were published between 1977 and 2010 and consisted mainly of case series (73%) (Table 1, available at http://aaojournal.org). From these studies, we classified the results of 103 different prognostic factors in evidence tables (e.g., Table 3, available at http://aaojournal.org). Fifty-three studies (62%) performed a multivariable analysis. From a total of 795 conclusions in the articles, 471 (59%) were univariate results and 324 (41%) were multivariable results.
We
Discussion
This review article provides a systematic overview of evidence of all studied prognostic factors for glaucomatous visual field progression. By using semiquantitative analysis, we classified 2 factors as definitely associated, 9 as probably associated, and 30 as possibly associated with glaucomatous visual field progression (Table 4, available at http://aaojournal.org).
To create our review, we searched for a method that would go beyond the existing nonsystematic, narrative reviews. We did not
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Manuscript no. 2011-797.
Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.