Original articleTear Film Aberration Dynamics and Vision-Related Quality of Life in Patients with Dry Eye Disease
Section snippets
Methods
The study was conducted in the Clinical Investigation Centre for Ocular Surface Pathology (Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, INSERM-DHOS CIC 503, Paris, France) in accordance with the Declaration of Helsinki, Scotland amendment, 2000. Ethics committee approval was obtained from the Comité de Protection des Personnes (Ile de France V, agreement number 10793), and all patients gave informed consent.
Patient Features and Vision-Related Quality of Life
The profile, clinical features, tear osmolarity, and OSDI scores of each group are detailed and compared in Table 1. A significant difference in the OSDI overall score as well as in OSDI subscores was found between DED patients and controls.
Comparative Analysis of Aberration Dynamics Between Groups
The time course of corneal HOAs is detailed for each group in Figure 1A, B. In dry eye patients, there was a significant variation in total corneal HOAs (P<0.01, repeated-measures analysis of variance), third-order coma (P<0.01), and third-order trefoil (P
Discussion
Approximately 5 million Americans 50 years and older are estimated to have dry eye.1 Dry eye disease refers to a multifactorial disease that can present in various ways; it recently was defined as the association of “symptoms of discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface.”8 All DED patients have in common pathologic tear film instability that impacts visual performance, adversely affecting activities of daily living. A consensus needs
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Manuscript no. 2011-1424.
Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.