Original articleChoroidal Thickness Measured by Spectral Domain Optical Coherence Tomography: Factors Affecting Thickness in Glaucoma Patients
Section snippets
Methods
Subjects were selected as a convenience sample of those from a tertiary referral practice of glaucoma who gave verbal informed consent and agreed to the additional testing at times when staff members were available to test them. The study followed the tenets of the Declaration of Helsinki and was approved by the Johns Hopkins Joint Committee for Clinical Investigation. Adherence to Health Insurance Portability and Accountability Act guidelines was maintained throughout the study. Eligible
Results
Seventy-four patients, 37 with glaucoma and 37 glaucoma suspects, met the eligibility criteria between October 2009 and February 2010. SD-OCT macular scans were obtained ≥1 eye in 73 of 74 subjects, and in ≥1 eye in 73 of 74 subjects for the peripapillary scans. Intraclass correlation coefficient (95% confidence interval [CI]) for the measures obtained by both graders in the 60 remeasured macular and peripapillary scans were 0.97 (0.95–0.98) and 0.98 (0.97–0.99), respectively. Images were
Discussion
Previous investigations of factors associated with choroidal thickness in normal or pseudophakic patients had determined that older persons and eyes with longer axial length or myopic refraction have a thinner choroid.20, 21, 22, 23, 24 Our study has found for the first time that a group of glaucoma suspect and glaucoma patients share these associations. Clearly, the aging process and axial length are closely related to choroidal thickness as well as being important risk factors for OAG
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Manuscript no. 2010-1201.
Financial Disclosure(s): The authors have made the following disclosures:
Harry A. Quigley - financial (research) support - Alcon, Heidelberg Engineering, and the NIH-NEI.
Supported in part by NIH research grant EY01765 (Core Facility Grant, Wilmer Institute), and by unrestricted gifts from the Leonard Wagner Trust, New York, NY, and Tom Forrester.
David S. Friedman - financial (research) support - Carl Zeiss Meditec.
Henry D. Jampel - paid consultant - Endo-Optics, Ivantis, Transcend, and Mobius; equity owner - Allergan.