Original ArticleLaser Peripheral Iridotomy in Primary Angle-Closure Suspects: Biometric and Gonioscopic Outcomes: The Liwan Eye Study
Section snippets
Patients
Detailed study procedures have been reported previously.7 In brief, 1405 persons aged 50 years and older were enrolled from Liwan District, Guangzhou, using cluster random sampling. Ethical approval was obtained from the Zhongshan University Ethical Review Board and the Ethical Committee of Zhongshan Ophthalmic Center. The study was conducted in accordance with the tenets of the World Medical Association’s Declaration of Helsinki, and all participants signed informed consent for participation.
Results
A total of 101 persons with occludable angles in both eyes were considered to be eligible for the study and were offered laser iridotomy, 72 of whom (71.3%) participated (38 right and 34 left eyes). The major reason for nonparticipation among otherwise eligible participants was the decline of consent. There was no difference between participants and nonparticipants in terms of age, gender, baseline IOP, ACD, and angle width (Table 1).
The iridotomy was patent in all but 1 eye after a single
Discussion
Laser peripheral iridotomy is the standard first-line intervention for acute and chronic angle closure.3 It prevents recurrence of acute episodes and eliminates the risk of acute attacks in fellow eyes.4, 12, 13, 14, 15 By allowing aqueous to flow directly through the iridotomy site, LPI equilibrates the pressure between the anterior and posterior chambers. Eliminating this pressure gradient flattens the iris, allowing the peripheral iris to fall backward, resulting in a wider angle
References (31)
- et al.
Accuracy of clinical estimates of intraocular pressure in Chinese eyes
Ophthalmology
(2000) - et al.
A prospective ultrasound biomicroscopy evaluation of changes in anterior segment morphology after laser iridotomy in Asian eyes
Ophthalmology
(2003) - et al.
Increase in iris-lens contact after laser iridotomy for pupillary block angle closure
Am J Ophthalmol
(1996) Long-term follow-up of laser iridotomy
Ophthalmology
(1981)- et al.
Acute primary angle closure in an Asian population: long-term outcome of the fellow eye after prophylactic laser peripheral iridotomy
Ophthalmology
(2000) - et al.
Acute intraocular pressure response to argon laser iridotomy
Ophthalmology
(1985) - et al.
The effect of phacoemulsification on aqueous outflow facility
Ophthalmology
(1997) - et al.
Comparison of prone-position, dark-room, and mydriatic tests for angle-closure glaucoma before and after peripheral iridectomy
Am J Ophthalmol
(1972) - et al.
Follow-up of angle-closure glaucoma suspects
Am J Ophthalmol
(1993) - et al.
Glaucoma in China: how big is the problem?
Br J Ophthalmol
(2001)
Who needs an iridotomy?
Br J Ophthalmol
Laser peripheral iridotomy for pupillary-block glaucoma
Ophthalmology
A randomised, prospective comparison of Nd:YAG laser iridotomy and operative peripheral iridectomy in fellow eyes
Eye
Provocation and medical treatment in post-iridectomy glaucoma
J Ocul Pharmacol
Primary angle closure glaucoma in Chinese and Western populations
Chin Med J (Engl)
Cited by (0)
Manuscript no. 2006-338.
The authors have no financial or other conflicts of interest concerning the article.
Dr He is supported by a University College London Graduate School Research Scholarship, a University College London Overseas Research Scholarship (no. 2001061054), and the Scientific and Technology Foundation of Guangdong Province, Guangzhou, China (grant no.: 2005B30901008). Dr Foster is supported by the Medical Research Council, London, United Kingdom (grant no.: G0401527); Wellcome Trust, London, United Kingdom (grant no.: 075110); and Richard Desmond Charitable Foundation (via Fight for Sight), London, United Kingdom. Prof Khaw is supported by the Medical Research Council (grant no.: G9330070); Moorfields Special Trustees, London, United Kingdom; and Michael and Isle Katz Foundation, London, United Kingdom.