Original articleComparison of Ultrahigh- and Standard-Resolution Optical Coherence Tomography for Imaging Macular Pathology
Section snippets
Materials and Methods
A prototype UHR OCT system suitable for performing studies in the ophthalmology clinic has been developed. In OCT imaging, the axial image resolution is determined by the coherence length of the light source, which is inversely proportional to the optical bandwidth of the light source. As the imaging light source for the UHR OCT system, we used a femtosecond titanium–sapphire laser specially developed by our laboratory that can generate a ∼125-nm bandwidth centered at a 815-nm wavelength. The
Results
We present a representative example of results from the following macular pathologies: full-thickness macular hole, central serous chorioretinopathy, macular edema, AMD (nonneovascular and neovascular), RPE detachment, epiretinal membrane, vitreomacular traction and retinitis pigmentosa, and chloroquine retinopathy.
It is helpful to first consider an UHR OCT image in a normal retina to facilitate the interpretation of UHR OCT and standard-resolution OCT images. Figure 1A shows a horizontal UHR
Patient 1: Full-Thickness Macular Hole
A 64-year-old woman with 20/50 vision in her left eye was diagnosed with a stage III macular hole upon clinical examination (Fig 2A). The standard-resolution StratusOCT and UHR OCT macular images in Figure 2B, C clearly visualized a full-thickness macular hole. Cystic structures associated with the macular hole are present and appear localized in the ONL and INL of the parafoveal region. The UHR OCT enables enhanced visualization of the smaller cystic structures in the ONL. External to the
Discussion
Ultrahigh-resolution OCT imaging of macular pathologies has been reported previously by Drexler et al.24 In that study, UHR OCT was used to image 56 eyes of 40 selected patients with different macular diseases, and it was found that UHR OCT can enhance visualization of intraretinal morphologic features and provide additional diagnostically important information.24 It was also demonstrated that UHR OCT can be used to evaluate the integrity of photoreceptor layers, their thickness changes, and
Acknowledgments
The authors gratefully acknowledge C. R. Baumal, T. R. Hedges III, C. Mattox, M. B. Raizman, E. Reichel, A. H. Rogers, O. S. Singh, and H. K. Wu of the New England Eye Center for providing patients for this study. They also thank A. Aguirre, S. Bourquin, R. Ghanta, P. Herz, and P. Hsiung for their participation in the development of UHR OCT imaging technology.
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Cited by (0)
Manuscript no. 2005-4.
Supported in part by the National Institutes of Health, Bethesda, Maryland (contract nos.: R01-EY11289, R01-EY13178, P30-EY13078); National Science Foundation, Arlington, Virginia (grant no.: ECS-0119452); Air Force Office of Scientific Research, Arlington, Virginia (contract no.: F49620-98-1-0139); Medical Free Electron Laser Program, Air Force Office of Scientific Research, Arlington, Virginia (grant nos.: F49620-01-1-0186, FWF P14218-PSY, FWF Y159-PAT, CRAF-1999-70549); Massachusetts Lions Eye Research Fund Inc., New Bedford, Massachusetts; Eye and Ear Foundation, Pittsburgh, Pennsylvania; Research to Prevent Blindness, New York, New York; and Carl Zeiss Meditec, Dublin, California.
Drs Fujimoto and Schuman receive royalties from intellectual property licensed to Carl Zeiss Meditec. Dr Drexler is a consultant for Carl Zeiss Meditec.