Original articleOrbital Invasion by Periocular Basal Cell Carcinoma
Section snippets
Patients and Methods
This is a 3-center retrospective study of all patients with orbital invasion by periocular BCC, who were seen between January 1985 and July 2004 (Royal Adelaide Hospital, January 1985–July 2004;(Royal Victorian Hospital, January 1989–July 2004; Royal Brisbane Hospital; January 1992–July 2004).
The criteria for selection were all cases of histologically confirmed BCC with radiologic or histologic evidence of orbital invasion. Orbital imaging with computed tomography (CT) or magnetic resonance
Results
There were 64 patients with a mean age of 70±13 years (median, 72 years; range, 35–93 years). Fifteen were females (23.4%) and 49 males (76.6%) (P<0.0001 compared with equal frequencies of primary periocular BCC in males and females as reported previously2). All patients were Caucasians.
In 54 patients (84.4%), this was a recurrent tumor, and in 10 patients (15.6%), it was the first presentation of the tumor. The mean duration from the first tumor excision to the diagnosis of orbital invasion in
Discussion
In this report, we presented the largest series of patients with orbital invasion by periocular BCC. It is an uncommon complication, and the reported incidence is considered to be lower than 5%. Payne et al7 reported that 8 of 273 periocular BCC (3.6%) required exenteration, and Perlman and Hornblass8 reported similar results (3.8%) in 106 patients with BCC. In more recent studies, Howard et al4 identified 11 patients (2.5%) with orbital invasion from a series of 440 patients with periocular
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Manuscript no. 2004-146.