Original articleThe Australian Mohs database, part II: Periocular basal cell carcinoma outcome at 5-year follow-up☆
Section snippets
Materials and methods
A prospective, noncomparative, multicenter, interventional case series of patients with periocular BCC treated with MMS in Australia and monitored by the Skin and Cancer Foundation is reported. The criteria for selection were all cases of periocular BCC treated by MMS between 1993 and 1996. Tumors treated outside this period were excluded from this study. The methods used are described in part I of this study report.6 Recurrence at 5-year post-MMS follow-up was recorded for all cases, in
Results
During 1993 to 1996, 819 periocular BCCs were treated by MMS. To identify any obvious differences in cases treated during this period, clinical features were compared with the remaining cases in the overall series.6 There was no difference in gender (P = 0.2795); however, patients treated during 1993 to 1996 were younger than those treated after 1996 (mean difference: 3.3 years; 95% CI: 1.6–4.9). More medial canthal BCCs (53% vs. 41%) and fewer lower eyelid BCCs (44% vs. 54%) were treated
Discussion
The Australian MMS database is the largest prospective nationwide series of high-risk periocular BCCs managed by MMS, using fresh-frozen tissue sections and with a strict 5-year follow-up. We found no recurrences for primary BCCs and a recurrence rate of 7.8% (exact 95% CI: 3.2%–15.4%) for previously recurrent BCCs. Strict 5-year recurrence rates are reported—that is to say, the recurrence rate for only those cases for which 5-year follow-up data were available. That the recurrence rate is so
Acknowledgements
The authors thank the Skin and Cancer Foundation Australia and the participating Mohs surgeons for providing the data for this research. The Mohs surgeons involved were Drs Phillip Artemi, Timothy Elliott, John Coates, Brian De'Ambrosis, Gregory Goodman, Irene Grigoris, Michelle Hunt, Dudley Hill, Shyamala Huilgol, David Leslie, Robert Paver, Shawn Richards, William Ryman, Robert Salmon, Margaret Stewart, Howard Studniberg, Carl Vinciullo, and Perry Wilson. The authors also thank Kristyn
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Manuscript no. 230068.