Correlated or not: Glaucoma prevalence and modern industrialization
Introduction
Glaucoma is a progressive optic neuropathy characterized by optic nerve damage and visual field loss. It is the second leading cause of blindness worldwide, largely due to POAG [1], [2]. It is estimated that there will be 60.5 million people globally with glaucoma in 2010, increasing to 79.6 million by 2020.
As a progressive optic neuropathy, the etiology of glaucoma is still not well understood. It has been suggested that this condition may result from the interaction among several environmental and genetic factors [3]. Genetics plays an important role in the growth of the eye, as demonstrated in various racial and family studies [4]. For example, a shallow anterior chamber was indicated as an inherited characteristic of Eskimos, which could explain the high prevalence of PACG among Eskimos, Chinese and Mongolians [5], [6], [7], [8], [9], [10]. On the other hand, among the black American population, POAG leads as the main cause of blindness [11], [12]. However, the situation seems to have changed in recent years due to the industrialization and urbanization in developing areas. The following epidemic investigation may explain such consequences as the changes in prevalence of POAG and PACG.
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The prevalence of POAG in urban and rural regions
Currently, the countries of the developing world are experiencing one of the most rapid of epidemiological transitions, characterized by increasing urbanization and changes in lifestyle. Previous studies reported that the prevalence of PACG was higher than that of POAG among Chinese and Mongolian populations [6], [7]. However, recent population surveys have found that the prevalence of POAG among urban residents has increased, and the urban prevalence is higher than the rural one [13] (Table 1
The prevalence of glaucoma in Asians
Previous studies have shown significant ethnic variations in glaucoma prevalence [5], [24]. POAG was the most common in populations of European and African ancestry [25], [26], while PACG was characteristic of the majority of primary glaucoma in Asian ethnic groups, with the exception of the Japanese [27], [28], [29]. Shiose et al. found that the prevalence of PACG in the Japanese national population survey in 1991 was 0.34%, while POAG was 2.62%, much higher than PACG [28]. A similar trend was
A secular change of the anterior chamber depth (ACD) level in arctic Eskimos
There are four Eskimo groups, including Greenland, Siberian, Alaskan, and Canadian Eskimos. The modern Eskimos are generally considered to be the descendants of a wave of migration of peoples who crossed the Bering Land Bridge from north-eastern Asia about 13,000 years ago, and they share various physiognomic and other anatomical traits with Mongolians. The Inuit people (Eskimos in North America) of Alaska, Canada and Greenland now suffer the highest rates of ACG in any population [43], [44],
The relationship between POAG and myopia
The correlation between glaucoma and myopia is believed to be correlated with several factors, such as (1) shearing forces exerted by sclera tension across the lamina cribrosa, (2) alteration in connective tissue, (3) elevated susceptibility of optic nerve to glaucomatous damage in myopic eyes, or (4) genetic factors [71]. It is realized that industrialization increases the prevalence of myopia since it brings more chances for higher education and an intense near-work environment. Investigators
Conflicts of interest statement
None declared.
Acknowledgments
This work was supported by the grants from the National Natural Science Foundation of China (30872830, XL) and (30872831, XZ).
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The first two authors contributed to this article equally.