Clinical studyLongitudinal Quality of Life Assessment of Patients with Hepatocellular Carcinoma after Primary Transarterial Chemoembolization
Section snippets
Study Design
Institutional review board approval was obtained for the study, in which prospective, nonrandomized, single-institution data collection with longitudinal analysis of HRQOL data was performed. HRQOL scores were obtained via the Short Form–36 (SF-36) Health Survey Forms (version 1) between October 2000 and October 2005. Study inclusion criteria required that patients have a diagnosis of HCC, receive no previous treatment (eg, surgical resection, transplant, systemic chemotherapy, external-beam
Results
During the course of this study, 196 patients underwent transcatheter chemoembolization at our institution, 116 of whom had HCC. A total of 73 patients who underwent 163 surveyed procedures met our study criteria, during which time 129 SF-36 HRQOL surveys were completed, resulting in a SF-36 completion rate of 79%. Incomplete SF-36 surveys were dispersed among the patients. Time between subsequent chemoembolization procedures was determined by patient-specific clinical and radiographic factors,
Discussion
Mental health scores improved in patients with HCC after 4 months of image-guided transcatheter tumor therapy with chemoembolization. A subset of patients who completed three or more chemoembolization procedures exhibited improved mental health scores after the first and second procedures. This subset also exhibited improvement of bodily pain scores, but worsening of vitality scores, after the first chemoembolization. A search of the English literature found no other longitudinal study
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None of the authors have identified a conflict of interest.