Case ReportCerebral Dural Sinus Thrombosis Associated with Adenomyosis: A Case Report
Introduction
Cerebral venous thrombosis (CVT) is an infrequent cerebrovascular disease, with an estimated incidence of .5% among all strokes.1, 2 Causes of CVT are heterogeneous.1 We report a case of adenomyosis-associated dural sinus thrombosis complicated by iron deficiency anemia (IDA) and increased serum carbohydrate antigen 125 (CA125) levels. We propose adenomyosis as a possible cause of CVT and briefly discuss its development.
Section snippets
Case Presentation
A 47-year-old woman experienced a sudden onset of generalized seizures. At presentation, the patient was somnolent and complained of headache. Her blood pressure was 106/70 mm Hg. She had no history of hypertension, diabetes, or dyslipidemia and had not been a habitual smoker. Her medical history was remarkable for adenomyosis. She was not pregnant or taking contraceptives. Ophthalmologic examination revealed no abnormalities in the optic fundi. However, brain fluid–attenuated inversion
Discussion
To our knowledge, ours is the first case of CVT associated with adenomyosis. We previously reported 4 adenomyosis cases complicated by cerebral infarction.3 Adenomyosis rarely causes cerebral embolism with increase in d-dimer and CA125 levels. In addition to ovarian cancer, CA125 is a marker of benign ovarian tumors, myoma uteri, and adenomyosis.4 CA125 is a mucinous protein that can promote blood hypercoagulability.5 Recently, several reports have suggested a strong association between CVT and
References (8)
- et al.
Cerebral venous thrombosis: an update
Lancet Neurol
(2007) - et al.
Cerebral venous thrombosis associated with iron deficiency anemia
J Stroke Cerebrovasc Dis
(2008) - et al.
Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/American Stroke Association
Stroke
(2011) - et al.
Cerebral infarcts associated with adenomyosis among middle-aged women
J Stroke Cerebrovasc Dis
(2012)
Cited by (9)
Successful management of cerebral venous sinus thrombosis due to adenomyosis: Case reports and literature review
2023, Clinical Neurology and NeurosurgeryCerebral Infarcts by Nonbacterial Thrombotic Endocarditis Associated with Adenomyosis: A Case Report
2018, Journal of Stroke and Cerebrovascular DiseasesCitation Excerpt :Despite the widespread location of arterial embolic infarction and multiple cerebral infarcts in different vascular territories, no cardioembolic sources have been found on echocardiography in these cases. Therefore, the authors concluded that the underlying mechanism of thromboembolism in adenomyosis is hypercoagulability rather than cardiogenic embolism.1,2 The distinct feature of our patient compared with the most previously reported cases was the presence of definite cardioembolic sources presenting with NBTE.
Recurrent embolic stroke associated with adenomyosis: A single case report and literature review
2023, Neurological SciencesChanges of coagulation function in patients with adenomyosis
2022, Chinese Journal of Obstetrics and Gynecology and PediatricsVenous thromboembolism and adenomyosis: A retrospective review
2020, Gynecology and Minimally Invasive Therapy
Conflicts of interest: The authors declare no financial or other conflicts of interest.