Clinical and Laboratory ObservationEfficacy of Propranolol in Hepatic Infantile Hemangiomas with Diffuse Neonatal Hemangiomatosis
Section snippets
Methods
We identified 8 infants with IHH and diffuse neonatal hemangiomatosis who were seen at 5 different institutions in France and Germany. The recorded information was collected from the medical charts.
Characteristics of the Patients
There were 4 girls and 4 boys aged 0.5 to 10 months. Five were premature. All had cutaneous lesions that appeared soon after birth. Of the 8 patients, 4 had multifocal hepatic lesions (4 to 20 lesions), and 4 had diffuse lesions (more than 20) (Figure, A). Lesions measured from 0.8 to 6.8 cm. Hepatomegaly was noted in 5 patients. Liver tests were measured for patient 7 only and were within normal ranges. Heart failure with high cardiac output and elevated thyroid stimulating hormone revealing
Discussion
The efficacy of propranolol in the treatment of cutaneous hemangiomas has been previously described.3, 4 Infants with subglottic hemangiomas, who were resistant to other established medical treatments were successfully treated with propranolol.5, 6 The efficacy of propranolol on hepatic hemangiomas has recently been reported in a single case.7 In our series of 8 infants, propranolol was effective in all patients. The dramatic improvement observed in our series cannot be attributed to
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Cited by (0)
The authors declare no conflicts of interest.