Original ArticleThree-Dimensional Ultrasound in Diagnosis of Adenomyosis: Histologic Correlation With Ultrasound Targeted Biopsies of the Uterus
Section snippets
Material and Methods
Symptomatic premenopausal patients scheduled to undergo hysterectomy at the Department of Obstetrics and Gynecology of the University of Connecticut (New Britain, CT) from March 2010 to January 2011 were included in this prospective study. Institutional review board approval was obtained before study initiation. All premenopausal patients referred for hysterectomy were offered the opportunity to participate in the study, and properly signed informed consent was obtained. Inclusion criteria were
Results
Fifty-four premenopausal women with mean (SD) age 42.1 (5.1) years (range, 34–54 years) underwent 2D/3D TVS and hysterectomy, with the prevalence of adenomyosis at histologic analysis of 66.6% (36/54). Twelve patients (age, 43.6 [5.2] years) had previously undergone endometrial ablation, and at the time of surgery, 10 patients (age, 40.7 [3.6] years) were receiving medical treatment, 7 with a gonadotropin-releasing hormone analog and 3 with a levonorgestrel-releasing intrauterine system
Discussion
Previous studies that evaluated the accuracy of ultrasonography in enabling the diagnosis of adenomyosis have reported sensitivity of 65% to 98% and specificity of 86% to 97% 6, 13, 14, similar to the present study, which demonstrated sensitivity of 90% and specificity of 83%, and comparable to the diagnostic capabilities of MRI, with sensitivity of 87% and specificity of 100% [8]. However, most of these studies, as well as our previous 3D TVS study [10], demonstrated high accuracy for
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