Case SeriesIntraoperative floppy-iris syndrome associated with use of antipsychotic drugs
Section snippets
Cases
Reporting of the current cases was covered by a study protocol titled “Epidemiologic study in ocular morphology and function,” which the Ethics Committee of Matsue Red Cross Hospital approved.
Discussion
Our 3 cases had common features of incomplete IFIS, no history of systemic selective α1-blocker use, a history of antipsychotic drug use, and concomitant glaucoma. Cases 1 and 3 had used the topical β-blocker timolol, and case 2 had used the topical αβ-blocker levobunolol to treat glaucoma. Although a possible association between the systemic αβ-blocker labetalol and IFIS was reported in one case,4 a multicentre study did not find an association between topical medications, including the
Disclosure
The authors have no proprietary or commercial interest in any materials discussed in this article.
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Cited by (12)
Drugs Affecting the Central Nervous System
2020, Drug-Induced Ocular Side Effects, Eigtht EditionAntipsychotic Drugs
2017, Side Effects of Drugs AnnualCitation Excerpt :A study (n = 1274) of intraoperative floppy-iris syndrome (IFIS) identified quetiapine, benzodiazepines and hypertension as risk factors for IFIS [35MC]. Three cases of IFIS with APs in a 39-year-old male, a 63-year-old male and a 65-year-old female are reported [36A]. A study (n = 495) of patients with schizophrenia or bipolar disorder found serum concentrations risperidone and quetiapine was correlated with worse verbal memory and verbal fluency for [37C].
Prospective analysis of anatomic features predisposing patients to intraoperative floppy iris syndrome
2024, Graefe's Archive for Clinical and Experimental OphthalmologyA Pharmacovigilance Study of Drug-Induced Glaucoma Utilizing the Japanese Adverse Event Reporting System
2023, Clinical OphthalmologyFloppy iris syndrome associated with specific medication intake: A narrative review
2023, Biomedical PapersIntraoperative floppy iris syndrome—What is new in systemic medication?
2022, Spektrum der Augenheilkunde
Orally presented at Asia-ARVO 2015 in Yokohama, Japan, Feb 16–19, 2015.