Journal of the American Medical Directors Association
Original StudyAssociation Between Gait Speed With Mortality, Cardiovascular Disease and Cancer: A Systematic Review and Meta-analysis of Prospective Cohort Studies
Section snippets
Methods
This systematic review was conducted according to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) criteria17 and the recommendations in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.18 The protocol of this systematic review and meta-analysis is pre-conceived, but not published, and is available upon request from the corresponding author.
Results
The search identified 7026 nonduplicated, potentially eligible studies. After excluding 6927 papers on the grounds of a review of their titles and abstracts, 99 full-text articles were examined, and 44 articles11, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69 were finally included in our meta-analysis (Supplementary Figure 1), with one paper11 giving information for 5
Discussion
In this meta-analysis, including 48 cohorts and more than 100,000 participants, we found that slow gait speed was associated with an increased risk of earlier mortality and incident CVD, whereas we did not observe a relationship between gait speed and incident cancer. After adjusting for multiple confounders, the risk-effect associated with a reduction of 0.1 m/s in gait speed was consistent with death and the onset of CVD, which was present after adjusting for publication bias, and our
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E.C. been a consultant and/or advisor to or has received honoraria from Nutricia, Wunder, and Akern.
The authors declare no conflicts of interest.