Food, drug, insect sting allergy, and anaphylaxisRelationship between red meat allergy and sensitization to gelatin and galactose-α-1,3-galactose
Section snippets
Study population
The study was undertaken in a mixed adult/pediatric specialty allergy/immunology practice in the Australian Capital Territory in southeastern Australia. The practice services the local inland metropolitan population and surrounding regional (including coastal) areas. Referrals were received from general medical practitioners, accident and emergency departments, and pediatricians. Patients were assessed by the first author (R.J.M.). Clinical and demographic data were entered prospectively into a
Patients' characteristics
Between 1995 and 2011, 1159 adults aged 18 to 101 years (423 male subjects) assessed by the first author (R.J.M.) were given a diagnosis of FA triggered by seafood (n = 284), peanut (n = 189), tree nuts (n = 188), systemic allergic reactions to fruits/vegetables (n = 134), wheat (n = 77), egg (n = 57), red meat (n = 40), sesame seed (n = 22), cow's milk (n = 21), or soybean (n = 8). Of 40 patients with red meat allergy identified, 18 (46%) were male and aged 18 to 78 years (median, 48 years),
Discussion
We have identified a significant relationship between adult-onset red meat allergy and sensitization and clinical reactivity to gelatin, which is supported by the results of intraoperative exposure (MG23 and MG24 and GC1 and GC2), accidental exposure (MG12), observed challenge (ID1-ID4), or claims of reactivity to oral gelatin. Consistent with previous studies, SPT responses to commercial meat extracts were relatively small and sometimes negative,19, 29 and IDT and in vitro test results were
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Supported in part by National Institutes of Health grants RO1 AI-20565, K08 AI085190, and R21 AI087985.
Disclosure of potential conflict of interest: T. A. E. Platts-Mills is a consultant for IBT/Viracor and has received honoraria and research support from Phadia/Thermo-Fisher. S. Commins is on the Cornerstone Therapeutics speakers' bureau and has received research support from the National Institutes of Health. The rest of the authors declare that they have no relevant conflicts of interest.