The Present and FutureJACC State-of-the-Art ReviewPathophysiology of Takotsubo Syndrome: JACC State-of-the-Art Review
JACC State-of-the-Art Review
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Central Illustration
Key Words
β-adrenergic signaling
catecholamines
inflammation
pathophysiology
stress
Takotsubo stunning
Takotsubo syndrome
Abbreviations and Acronyms
ANS
autonomic nervous system
APD
action potential duration
ATP
adenosine triphosphate
βAR
β-adrenoreceptor
cAMP
cyclic adenosine monophosphate
ECG
electrocardiography
iPSC-CMs
inducible pluripotent stem cell-derived cardiomyocytes
LV
left ventricle
MIBG
123I-metaiodo-benzylguanidine
NO
nitric oxide
PCr
phosphocreatine
SERCA2a
sarcoplasmic reticulum (SR) Ca2+-adenosine-triphosphatase 2a
TTS
Takotsubo syndrome
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