Quarterly Focus Issue: Heart FailureState-of-the-Art PaperSympathetic Nervous System Activation in Human Heart Failure: Clinical Implications of an Updated Model
State-of-the-Art Paper
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Key Words
baroreceptor reflex
exercise
heart failure
human
norepinephrine
sleep apnea
sympathetic nervous system
Abbreviations and Acronyms
BP
blood pressure
CNES
cardiac norepinephrine spillover
CPAP
continuous positive airway pressure
CSA
central sleep apnea
HF
heart failure
HR
heart rate
HRV
heart rate variability
LBNP
lower body negative pressure
MSNA
muscle sympathetic nerve activity
NE
norepinephrine
OSA
obstructive sleep apnea
RNES
renal norepinephrine spillover
TNES
total body norepinephrine spillover
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Dr. Floras holds the Canada Research Chair in Integrative Cardiovascular Biology, is a Career Investigator of the Heart and Stroke Foundation of Ontario, and receives operating grant support from the Canadian Institutes of Health Research (MOP 82731; MOP 85052; MT 9721) and the Heart and Stroke Foundation of Ontario (PRG 5276; T4983; NA 6298; NA 6407) for studies of neural regulation of the circulation in human heart failure. He is a coinvestigator on a recently awarded Canadian Institutes of Health Research University–Industry operating grant to evaluate the treatment of sleep apnea in heart failure. Respironics is the industrial partner.
Copyright © 2009 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.