Original articleThe relationship between duration of psoriasis, vascular inflammation, and cardiovascular events
Section snippets
Materials and methods
Detailed descriptions of study approvals, data sources, and methods are available online.9 Study approval for the interventional cohort study was obtained from the National Heart, Lung, and Blood Institute (NHLBI) Institutional Review Board in accordance with the Declaration of Helsinki. All Guidelines for Good Clinical Practice (GCP) and those set forth by the National Institute of Health (NIH) Radiation Safety Commission and in the Belmont Report (National Commission for the Protection of
NIH cohort
The NIH cohort comprised 190 patients with mild-to-moderate psoriasis (Supplemental Table I; available at http://www.jaad.org), who were primarily middle-aged men (57% men), overweight, with mild insulin resistance (median insulin resistance of 2.77), but at low CV risk by Framingham risk score. Vascular inflammation assessed by TBR (mean ± SD = 1.70 ± 0.26) demonstrated increased vascular inflammation.10 Strong associations with vascular inflammation were seen for male sex, smoking, Framingham
Discussion
We utilized a human imaging study and a population-based study to investigate whether the duration of psoriasis increases the risk for CVD and MACEs, and we have presented novel and convincing evidence to suggest a detrimental effect of psoriasis duration on CVD beyond traditional CV risk factors, even in patients with low CV risk scores. Notably, every 1 SD increase in duration of psoriasis increases the TBR by 2.5%, which roughly translates into an absolute increase of 10% in future adverse
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The work at the National Institutes of Health cohort was supported by the National Heart, Lung and Blood Institute Intramural Research Program (HL006193-02). Dr Gelfand's role in this study was supported by National Institute of Arthritis and Musculoskeletal and Skin Diseases grant K24-AR064310.
Disclosure: Dr Egeberg has received research funding from Pfizer and Eli Lilly and honoraria as consultant and/or speaker from Pfizer, Eli Lilly, Novartis, Galderma, and Janssen Pharmaceuticals. Dr Skov has been a paid speaker for Pfizer, AbbVie, Eli Lilly, Novartis, and LEO Pharma and has been a consultant or served on advisory boards with Pfizer, AbbVie, Janssen Cilag, Novartis, Eli Lilly, LEO Pharma, and Sanofi; she has served as an investigator for Pfizer, AbbVie, Eli Lilly, Novartis, Amgen, Regeneron, and LEO Pharma and received research and educational grants from Pfizer, AbbVie, Novartis, Sanofi, Janssen Cilag, and Leo Pharma. Dr Mallbris is currently employed by Eli Lilly. Dr Gislason is supported by an unrestricted research scholarship from the Novo Nordisk Foundation and reports research grants from Pfizer, Bristol-Myers Squibb, AstraZeneca, Bayer, and Boehringer Ingelheim. Dr Wu has received research funding from AbbVie, Amgen, AstraZeneca, Boehringer Ingelheim, Coherus Biosciences, Dermira, Eli Lilly, Janssen, Merck, Novartis, Pfizer, Regeneron, Sandoz, and Sun Pharmaceutical Industries; he is a consultant for AbbVie, Amgen, Celgene, Dermira, Eli Lilly, Pfizer, Regeneron, and Sun Pharmaceutical Industries. In the previous 12 months Dr Gelfand has served as a consultant for and received honoraria from Coherus (data safety and monitoring board), Dermira, Janssen Biologics, Merck (data safety and monitoring board), Novartis Corp, Regeneron, Sanofi and Pfizer Inc; he receives research grants (to the Trustees of the University of Pennsylvania) from Abbvie, Janssen, Novartis Corp, Regeneron, Sanofi, Celgene, and Pfizer Inc; and he has received payment for CME work related to psoriasis that was supported indirectly by Lilly and Abbvie. Dr Gelfand is a co–patent holder of resiquimod for treatment of cutaneous T-cell lymphoma. Dr Mehta is a full-time US government employee and receives research grants to the NHLBI from AbbVie, Janssen, Novartis and Celgene. No other potential conflicts of interest were declared by the authors.
Dr Egeberg (Danish cohort) and Dr Mehta (National Institutes of Health cohort) had full access to all of the data in the study and take responsibility for integrity of the data and accuracy of the data analysis. Drs Egeberg, Skov, Mallbris, Gislason, Gelfand, and Mehta are responsible for the study concept and design. Drs Joshi, Ahlman, Rodante, Lerman, Gelfand, and Mehta (National Institutes of Health cohort) and Drs Egeberg and Gislason (Danish cohort) are responsible for acquisition, analysis, and interpretation of data. Drs Egeberg and Mehta are responsible for drafting of the manuscript. All authors the are responsible for critical revision of the manuscript for important intellectual content. Drs Egeberg, Gislason and Joshi are responsible for statistical analysis. Dr Mehta obtained funding. Drs Egeberg, Skov, Gislason, and Mehta are responsible for administrative, technical, or material support, and Drs Egeberg and Mehta are responsible for study supervision.
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