LetterTreatment of refractory fingernail onychomycosis caused by nondermatophyte molds with methylaminolevulinate photodynamic therapy
References (7)
- et al.
Onychomycosis caused by nondermatophytic molds: clinical features and response to treatment of 59 cases
J Am Acad Dermatol
(2000) - et al.
Photodynamic therapy of onychomycosis caused by Trichophyton rubrum
J Am Acad Dermatol
(2008) - et al.
Onychomycosis: diagnosis and definition of cure
J Am Acad Dermatol
(2007)
Cited by (54)
Photoantimicrobials in agriculture
2022, Journal of Photochemistry and Photobiology B: BiologyPhotodynamic therapy treatment of superficial fungal infections: A systematic review
2020, Photodiagnosis and Photodynamic TherapyCitation Excerpt :7/7 patients were mycological cured and 5/7 clinical cured in the case study by Oliveira et al. (n = 7) at follow-up [20] and one open-label clinical study (n = 8 patients) demonstrated 6/8 mycological cure at follow-up [21]. All four cases treating onychomycosis with MAL-PDT obtained complete cure [7,22,23], but one case experienced recurrence at follow-up [22]. One case achieved mycological and clinical cure after urea pretreatment and nail abrasion followed by porphyrin-PDT treatment of onychomycosis [24].
Treatment and management strategies of onychomycosis
2020, Journal de Mycologie MedicaleCitation Excerpt :Also, A review conducted on 5-aminolevulinic acid as photosensitizer showed penetration issues, making it not ideal for treatment [127]. Gilaberte Y et al. [128] used photodynamic therapy with 16% methylamino levulinate cream (MAL). 40% urea ointment was used to soften the nail plate and methylamino levulinate cream was applied.
Onychomycosis: Treatment and prevention of recurrence
2019, Journal of the American Academy of DermatologyCitation Excerpt :In another study (n = 22), the mycologic cure rate was 100%, and the complete cure rates were 63.6% and 100% in patients with severe and mild to moderate onychomycosis, respectively.134 Across the 6 published PDT onychomycosis studies, negative microscopy or culture was found in 67% of patients (n = 58).133,134,142-145 Some disadvantages of PDT include the requirement for pretreatment with nail avulsion or urea, numerous sessions, and pain.133,134
In situ production of ROS in the skin by photodynamic therapy as a powerful tool in clinical dermatology
2016, MethodsCitation Excerpt :There is some evidence of Herpes Simplex Virus infection (HSV) [110] and molluscum contagiosum [111] virus lesions responding to PDT treatment. Cutaneous mycoses have shown resolution in selected cases with good responses obtained in some series of onychomycosis [112]. It is also an acceptable therapeutic approach for refractory Malassezia folliculitis [113] or deep seated mycosis such as sporotrichosis [114].
Supported by grant PI120/09 from the Department of Science, Technology and University of Aragón, Spain.
Conflicts of interest: None declared.