DermatopathologyBasaloid squamous cell carcinoma of the skin
Section snippets
Case report
A 59-year-old white woman was referred to the Vanderbilt University Dermatology Clinic for evaluation before kidney transplant surgery. In 1995 she had been diagnosed with antineutrophilic cytoplasmic antibody–positive small vessel vasculitis, which eventuated in necrotizing and crescentic glomerulonephritis. End-stage renal disease ensued despite the administration of prednisone, cyclophosphamide (Cytoxan), cyclosporine, azathioprine, and rituximab. In May 2005 a biopsy was performed on a
Discussion
BSCCs have a predilection for the supraglottis, larynx, base of the tongue, and pyriform sinus, although they have been described as arising elsewhere, including the palate, buccal cavity, nasopharynx, floor of the mouth, trachea, esophagus, and tonsils as well.4, 7, 12, 13 Aside from the upper aerodigestive tract, BSCCs have also been reported in the uterine cervix, lung, and thymus.7, 8 The most common presenting symptoms are bleeding and hoarseness. A strong association with tobacco and
References (30)
- et al.
Basaloid-squamous carcinoma of the tongue, hypopharynx, and larynx: report of 10 cases
Hum Pathol
(1986) - et al.
Distinction of basaloid squamous cell carcinoma from adenoid cystic and small cell undifferentiated carcinoma by immunohistochemistry
Hum Pathol
(1998) - et al.
Is there an epidemiological link between human papillomavirus DNA and basaloid squamous cell carcinoma of the pharynx
Oral Oncol
(2007) - et al.
Course and prognosis of basaloid squamous cell carcinoma of the head and neck: a case-control study of 62 patients
Eur J Cancer
(2008) - et al.
A rare nasal tip skin metastasis of a basaloid squamous cell carcinoma of the larynx
Am J Med
(2008) - et al.
Basaloid squamous cell carcinoma of the head and neck: a clinicopathologic and immunohistochemical study of 40 cases
Am J Surg Pathol
(1992) - et al.
Basaloid and warty carcinomas of the vulva: distinctive types of squamous cell carcinoma frequently associated with human papillomaviruses
Am J Surg Pathol
(1993) - et al.
Basaloid squamous cell carcinoma of the esophagus: diagnosis and prognosis
Cancer
(1997) - et al.
Basaloid squamous cell carcinoma: a distinctive human papilloma virus-related penile neoplasm: a report of 20 cases
Am J Surg Pathol
(1998) - et al.
Basaloid squamous cell carcinoma of the head and neck
Laryngoscope
(2000)
Basaloid squamous cell carcinoma of the head and neck
Curr Opin Otolaryngol Head Neck Surg
p63 immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma
Mod Pathol
Basaloid squamous cell carcinoma of the external auditory canal: case report
Eur Arch Oto Rhino Laryngol Head Neck
Basaloid squamous cell carcinoma of the head and neck is a mixed variant that can be further resolved by HPV status
Am J Surg Pathol
Expression of PCNA and bcl-2 in basaloid squamous cell carcinoma of the larynx: a controlled study
Ear Nose Throat J
Cited by (34)
A diagnostic approach to basaloid neoplasms of the skin: squamous is red; basals are blue but alas! If only that were true
2024, Diagnostic HistopathologyBasal cell carcinoma vs basaloid squamous cell carcinoma of the skin: An immunohistochemical reappraisal
2015, Annals of Diagnostic PathologyCitation Excerpt :In contrast, only 16% of BSCCs showed positive staining with that marker. That finding corroborates data in prior studies that generally showed the absence of Ber-EP4 in SCC, including its basaloid variant [2,3,33]. This observation possibly is explained by the fact that EpCAM expression is lost in terminally differentiated cells such as keratinocytes and thus is also lost in squamous carcinomas [34].
An unusual case of pilonidal p16 positive squamous cell carcinoma-a case report
2024, Journal of Surgical Case ReportsMetastatic Basal Cell Carcinoma: An Unexpected Diagnosis in a Young Patient With Back Pain
2022, American Journal of Dermatopathology
Funding sources: None.
Conflicts of interest: None declared.