Case reportNail dystrophy and bony involvement in chronic sarcoidosis
Section snippets
Discussion
Cutaneous sarcoidosis occurs in 20% to 35 % of patients with sarcoidosis and often presents with the onset of disease.1 However, nail dystrophy in sarcoidosis occurs less frequently, ranging from 1 in 400 patients2 to 3 in 188,3 meaning it is either uncommon or underreported.
The most common nail plate changes described in sarcoidosis include opacity, fragility, thickening, layering, convexity, longitudinal ridging, pitting, atrophy, and nail loss.2, 4, 5, 6, 7 Splinter hemorrhage4 and red or
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Cited by (29)
Nail is Systemic Disorders: Main Signs and Clues
2021, Dermatologic ClinicsCitation Excerpt :Finger clubbing and osteoarthropathy are rarely associated to pulmonary sarcoidosis.20 Nail disease can be treated with high-potency topical steroids, intralesional steroid injection, or systemic treatment (oral corticosteroids and/or hydroxychloroquine), but with poor effect on the bony alteration.14–16 In cutaneous graft-versus-host disease (GVHD), nails are involved in one-third to one-half of the patients.21–23
Sarcoidosis
2021, Encyclopedia of Respiratory Medicine, Second EditionMultiple crusty ulcerative lesions revealing systemic sarcoidosis
2020, Annales de Dermatologie et de VenereologieCutaneous Sarcoidosis
2015, Clinics in Chest MedicineCitation Excerpt :Nail changes seen in sarcoidosis are highly variable and can include splinter hemorrhages, thinning, pitting, onycholysis, subungual debris, scarring, trachyonychia, color changes, or complete absence of the nail (anonychia) (Fig. 13).93–99 The presence of significant nail changes has a high association with underlying bony cysts, most often in the distal phalynx and may signify a chronic course of systemic disease.95 Oral involvement of sarcoidosis is rare and morphologically can simulate cutaneous diseases with the presence of papules; nodules; erythema, including strawberry gums; and ulcerations.100–103
Sarcoidosis
2015, Dermatologic ClinicsCitation Excerpt :Anogenital sarcoidosis, although rare, may manifest with tender indurated papules and nodules, pruritic scaly plaques, or swelling.91–94 Nail manifestations caused by sarcoidosis include subungual hyperkeratosis, pitting, clubbing, onychorrhexis, trachyonychia, splinter hemorrhages, paronychia, pterygium, onycholysis, nail plate thinning, dactylitis, longitudinal ridging, and nail bed discoloration.95–97 A review of 33 cases of nail sarcoidosis reported that bone cysts were present on radiographic imaging in almost half of the cases and that all had systemic involvement.95
Nail abnormalities associated with systemic pathologies
2013, Clinics in Dermatology
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Conflicts of interest: None declared.