ReportDietary glycemic index and glucose, insulin, insulin-like growth factor-I, insulin-like growth factor binding protein 3, and leptin levels in patients with acne
Section snippets
Participants and protocol
This prospective cohort study was designed to examine associations among glycemic index of daily diet, serum insulin levels, and acne. A total of 49 university students with severe, moderate, or mild acne seen in our outpatient department and 42 healthy students who did not have acne (control group) were included in the study. The local ethics committee approved the study protocol.
At the initial visit the patients' age, sex, weight, height, and duration of acne were recorded. Body mass index
Results
Among the 49 university students with acne, 19 (38.8%) were male and 30 (61.2%) were female. The ages were between 19 and 34 years (mean: 20.37 ± 1.944 years) and the duration of the condition lasted from 1 to 10 years (mean 3.7). Seventeen patients (34.6%) had mild, 27 (55.1%) had moderate, and 5 (10.2%) had severe acne. Control group constituted of 42 people, 16 (39.1%) male and 36 (61.9%) female. Patient and control groups were matched according to their age and sex. Table I shows the
Discussion
Non-Westernized diets are known to be free of processed foods, cereal grains, dairy products, refined sugars, and refined oils and almost entirely comprise unprocessed fresh fruits, vegetables, and lean meats, fish, and seafood.31 Dietary attitudes of the Turkish population resembles that of the Western population especially in the last decade. This resemblence is even moreso in university students regarding consumption of fast foods. Therefore, higher incidence of acne could be expected
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Cited by (81)
Diet and acne: A systematic review
2022, JAAD InternationalCitation Excerpt :One trial was nonrandomized. Overall, 17.9% (5/28) of the observational studies exclusively assessed the association between GI/glycemic load and acne (Table I).19-23 Overall, 35.7% (10/28) exclusively commented on the association between dairy and acne (Table II),24-33 and 46.4% (13/28) described the associations of dairy products and GI/glycemic load with acne (Table III).34-46
Non-conventional therapeutical approaches to acne vulgaris related to its association with metabolic disorders
2022, European Journal of PharmacologyApproaches to limit systemic antibiotic use in acne: Systemic alternatives, emerging topical therapies, dietary modification, and laser and light-based treatments
2019, Journal of the American Academy of DermatologyDifferences in Dietary Glycemic Load and Hormones in New York City Adults with No and Moderate/Severe Acne
2017, Journal of the Academy of Nutrition and DieteticsCitation Excerpt :Although these results are in accordance with the current study, the researchers only measured biological factors associated with acne among a subset of the sample, limiting the study’s generalizability and our understanding of the diet-acne relationship. In contrast to the current study, Kaymak and colleagues30 did not find differences in dietary GI/GL among participants with and without acne. In addition, the researchers observed greater IGFBP-3 concentrations among participants with acne compared to those without acne.
Dietary glycemic factors, insulin resistance, and adiponectin levels in acne vulgaris
2016, Journal of the American Academy of DermatologyCitation Excerpt :Although there was no statistically significant difference in the consumption of milk and dairy proteins between the patients with acne vulgaris and the control group, this result might not reflect long-term consumption habits, as the diet records that provided the data only covered the 7 days before the study. Not all cross-sectional studies have demonstrated an association between a low-glycemic-index/-load diet and acne.23,24 Kaymak et al24 reported that no significant differences were observed between patients with acne and control subjects in terms of serum glucose, insulin, IGF-1, IGFBP-3, overall glycemic index, dietary glycemic load, and leptin levels.
Adolescents’ self perceived acne-related beliefs: from myth to science
2019, Anais Brasileiros de DermatologiaCitation Excerpt :Sweets, fatty foods, and change in dietary habits towards healthier food were statistically more frequently reported by girls compared to boys, similarly as reported among Greek adolescents.9 The acnegenic properties of both hyperinsulinemic foods and consumption of dairy proteins, which increase concentrations of insulin and insulin-like growth factor (IGF-1), have been proposed by Melnik et al.31 Although Kaymak et al.32 did not observe correlation of acne with serum glucose and insulin, several other studies conducted by groups of authors30,33,34 revealed that the dietary glycemic index (GI), saturated fat, trans-fat, and milk may influence or aggravate acne, and the role of milk is further acknowledged by the Italian group.35 In the present study, dairy products were not recognized as a significant acne-aggravating factor.
Funding sources: None.
Conflicts of interest: None declared.