Original articleClinical endoscopyA phenotypic analysis shows that eosinophilic esophagitis is a progressive fibrostenotic disease
Section snippets
Study design, data source, and phenotype definitions
This was a retrospective study conducted at the University of North Carolina Center for Esophageal Diseases and Swallowing. By using the University of North Carolina EoE clinicopathology database from 2001 to 2011, we included patients with an incident diagnosis of EoE made at the University of North Carolina who met consensus diagnostic guidelines. Specifically, all patients had symptoms of esophageal dysfunction, ≥15 eosinophils per high-power field (eos/hpf) (hpf area = 0.24 mm2), and did
Characteristics of EoE cases
A total of 379 EoE cases were identified in the database (Table 1). The mean age was 25 years (6 months-82 years), 73% were male, and 81% were white. The most common symptoms were dysphagia (66%), heartburn (39%), and food impaction (28%), with a mean duration of symptoms before diagnosis of 7 years. More than one-third of patients had some form of atopy. On endoscopy, typical findings of EoE were common, with 40% having esophageal rings and 40% having linear furrows. The average maximum
Discussion
With increasing knowledge about EoE, the variability in the disease has been recognized,2 and differences in characteristics between adults and children7, 9, 10, 11, 12 and by race or sex have been described.29, 30, 31 This has raised the question of whether underlying EoE phenotypes are responsible for different clinical presentations and outcomes and whether such phenotypes might impact or be the result of the natural history of the condition. The purpose of this study was to characterize
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DISCLOSURE: This work was supported, in part, by National Institutes of Health Award K23 DK090073. No other financial relationships relevant to this publication were disclosed.
If you would like to chat with an author of this article, you may contact Dr Dellon at [email protected].
See CME section: p. 663.