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BRCA mutations and reproduction

https://doi.org/10.1016/j.fertnstert.2017.12.004Get rights and content
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Deleterious mutations in BRCA1 or BRCA2 genes have long been recognized as independent risk factors, mostly for breast and ovarian cancer. Numerous studies have evaluated the molecular processes involving these genes, the pathophysiology of BRCAness, follow up options and modes of prophylaxis. The fertility of BRCA carriers, however, has not been widely investigated. The aim of the present work is to review the literature pertaining to this issue.

Key Words

BRCA
preimplantation genetic diagnosis (PGD)
premature ovarian insufficiency

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H.D. has nothing to disclose. T.P. has nothing to disclose. N.L. has nothing to disclose.