Original articleReduced pretreatment ovarian reserve in premenopausal female patients with Hodgkin lymphoma or non-Hodgkin-lymphoma—evaluation by using antimüllerian hormone and retrieved oocytes
Section snippets
Materials and methods
Between January 2007 and November 2011, a total of 49 female patients with an initial diagnosis of HL or NHL presented for counseling on fertility preservation methods before receiving cytotoxic chemotherapy. Of these 49 patients, 38 agreed to take part in this study (i.e., study group). Blood was taken as part of the consultation to measure AMH levels as a marker of the ovarian reserve.
The control group was composed of healthy, voluntary, age-matched women with a normal body mass index and a
Results
The mean age of the patients in the study group and those of the control group was 25.5 years (range 18–33 years). Thirty-one patients were affected by Hodgkin disease and seven by a non-Hodgkin lymphoma. Nine patients were found to have breast cancer symptoms at the time of diagnosis.
Twenty-three patients had stage I/II disease and 15 patients stage III/IV. The mean age of the patients with stage I/II disease was 25.22 years (range 18–38 years) and was 25.93 years (range 20–33 years) in the
Discussion
It has been shown that the sperm quality in men with HL or NHL is already significantly reduced before the start of chemotherapy 9, 10, 11, 12. We therefore analyzed whether reduced fertility in the form of a reduced ovarian reserve also exists in women with HL and NHL. Antimüllerian hormone has established itself as a valuable parameter that reflects the ovarian reserve well (14). Evaluation of AMH levels in our collective of lymphoma patients and com-parison with healthy age-matched controls
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Cited by (0)
B.L. has nothing to disclose. T.F. has nothing to disclose. M.v.W. has nothing to disclose. M.S. has nothing to disclose. S.H. has nothing to disclose. J.H. has nothing to disclose. M.H. has nothing to disclose.