Case reportSuccessful treatment of unresponsive thin endometrium
Section snippets
Case report
On the basis of anecdotal reports and a US patent application (7), we sporadically used subcutaneously injected G-CSF (Neupogen, Filgastrim; Amgen Manufacturing, Thousand Oaks, CA), off label and with appropriate experimental informed consent, in suspected implantation failure.
Because diagnosis of implantation failure is always tentative, clinical effects of G-CSF in this indication are difficult to assess. In contrast, however, potential proliferative effects on endometrium can be
Discussion
We here report four IVF patients, in two infertility centers, with extraordinarily poor endometrial quality, despite maximal standard therapy with estrogen and vasodilator therapy. All four without G-CSF perfusion in all likelihood would have experienced cycle cancellation or other unsatisfactory alternative treatments, reducing pregnancy chances and increasing costs as well as emotional distress.
These cases are reported ahead of two ongoing, prospectively randomized studies of G-CSF because of
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N.G. has nothing to disclose. A.V. has nothing to disclose. D.H.B. has nothing to disclose.