Isopropanolic Cimicifuga racemosa is favorable on bone markers but neutral on an osteoblastic cell line

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Postmenopausal women treated with an isopropanolic extract of Cimicifuga racemosa underwent a decrease in the urinary concentration of N-telopeptides, a marker of bone resorption, and an increase in alkaline phosphatase, a marker of bone formation, at the third month of therapy. Serum from treated women did not modify the activity of alkaline phosphatase or the expression of three genes, runt-related transcription factor-2 (Runx-2), alkaline phosphatase, and osteocalcin, when added to the MC3T3-E1 osteoblastic cell line.

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M.A.G. has nothing to disclose. B.P. has nothing to disclose. C.H. has nothing to disclose. J.J.T. has nothing to disclose. A.C. has nothing to disclose.

Supported by Grants FIS 06/154 from Fondo de Investigación Sanitaria (FIS, Madrid, Spain), Red HERACLES RD06/0009 from Instituto Carlos III (Ministerio de Sanidad y Consumo; Madrid, Spain) and 045/2007 from Conselleria de Sanitat (Generalitat Valenciana, Valencia, Spain). M.A.G. is a recipient of a research contract from Fondo de Investigación Sanitaria, Consellería de Sanitat (Generalitat Valenciana).