In vitro fertilizationNeuromotor development and mental health at 5.5 years of age of singletons born at term after intracytoplasmatic sperm injection ICSI: results of a prospective controlled single-blinded study in Germany
Section snippets
Study Design
The aim of the study was to assess a cohort of children conceived by ICSI at the age of 4–6 years (who had been previously assessed at birth). The primary outcome measure was the intelligence measured with the Kaufman Assessment Battery for Children (K-ABC). Other measures were biometric data, health status, acute, chronic, and childhood illnesses, development, and data on family functioning.
The study was designed as a prospective controlled single blinded study with a one-sided equivalence
Participation
We asked 574 eligible ICSI and 2,577 control parents to take part in the study via postal enquiry. A total of 323 ICSI parents (56.3%) and 442 control parents (17.2%) were willing to take part in the study. The examination could be performed in 295 ICSI and 287 control children. A total of 19 ICSI children and 14 controls had to be excluded, because the examination revealed that they did not meet the inclusion criteria. Finally, the data of 276 ICSI and 273 control children were available for
Discussion
We could show that the ICSI singletons born at term showed normal development with good neurologic health and good motor skills at the age of 5.5 years.
Except for a higher incidence of strabismus in the control children, we did not observe any difference in the detailed neurologic examination between the groups. Our neurologic examination included a detailed standardized motor test with 18 different subtests. Most other studies have assessed only fine and gross motor skills, and only a few
Acknowledgments
The authors thank the study's secretary, Ms. Kerstin Greulich, for her technical support and commitment to the study. The pediatricians Björn Becker, Meike Bendiks, Andreas Entenmann, and Anja Karpa and the psychologist Ricarda Gross examined all of the children. The authors thank them for their commitment. They especially thank the participating families for their time and cooperation.
References (32)
- et al.
Atypical decondensation of the sperm nucleus, delayed replication of the male genome, and sex chromosome positioning following intracytoplasmic human sperm injection (ICSI) into golden hamster eggs: does ICSI itself introduce chromosomal anomalies?
Fertil Steril
(2000) - et al.
Impact of intracytoplasmativ sperm injection on the activation and fertilization process of oocytes
Reprod Biomed Online
(2001) - et al.
Fertilization and preimplantation development after intracytoplasmatic sperm injection
Reprod Biomed Online
(2001) - et al.
Genomic imprinting in disruptive spermatogenesis
Lancet
(2004) - et al.
Neurological sequelae in children born after in-vitro fertilisation: a population-based study
Lancet
(2002) - et al.
Postnatal growth and health in children born after cryopreservation as embryos
Lancet
(1998) - et al.
Development of children born after ovarian superovulation induced by long-acting gonadotropin-releasing hormone agonist and menotropins, and by in vitro fertilization
J Pediatr
(1994) - et al.
Congenital malformations and psychosocial development in children conceived by in vitro fertilization
J Pediatr
(1989) - et al.
Outcome in the second year of life after in-vitro fertilisation by intracytoplasmic sperm injection: a UK case-control study
Lancet
(2001) - et al.
Mental development of 201 ICSI children at 2 years of age
Lancet
(1998)
A prospective longitudinal study of the physical, psychomotor, and intellectual development of singleton children up to 5 years who were conceived by intracytoplasmic sperm injection compared with children conceived spontaneously and by in vitro fertilization
Fertil Steril
Pregnancy course and outcome after intracytoplasmic sperm injection: a controlled, prospective cohort study
Fertil Steril
Assisted reproduction—the epigenetic perspective
Hum Reprod Update
Human male infertility: chromosome anomalies, meiotic disorders, abnormal spermatozoa and recurrent abortion
Hum Reprod Update
Hospital care utilization of infants born after IVF
Hum Reprod
Imprinting diseases and IVF: Danish national IVF cohort study
Hum Reprod
Cited by (43)
Six-year follow-up of children born from vitrified oocytes
2021, Reproductive BioMedicine OnlineA comparison of metabolic health parameters in ICSI-conceived and naturally conceived adolescents
2020, Reproductive BioMedicine OnlineCitation Excerpt :This was a prospectively controlled study with 14- to 17-year-old singleton adolescents born using intracytoplasmic sperm injection (ICSI) and their mothers. The adolescents were part of a study cohort that has already been evaluated twice: the first time at birth (Katalinic et al., 2004), the second time at the age of 4–6 years (Ludwig et al., 2009), and now for a third time at the mean age of 16 years. The control group consisted of adolescents born by natural conception and their mothers.
Speech and language development of children born following assisted reproductive technologies
2020, International Journal of Pediatric OtorhinolaryngologyCitation Excerpt :A variety of studies were performed in different aspects of development in these children [1,12,13]. These aspects include cognitive [14,15], behavioral [16–18], neuromotor [14,19,20], and speech and language characteristics [4,14]. Speech and language capabilities of children born within these techniques were targeted in some studies [4,21,22].
Subfertility factors rather than assisted conception factors affect cognitive and behavioural development of 4-year-old singletons
2016, Reproductive BioMedicine OnlineAre children born through Intra-Cytoplasmic Sperm Injection (ICSI) having a lower intelligence quotient?
2016, Middle East Fertility Society Journal
Funded by the Deutsche Forschungsgemeinschaft (DFG) (LU801/2-1, LU801/2-2).