Original articleImpact of Chronic Obstructive Pulmonary Disease with Pulmonary Hypertension on Both Left Ventricular Systolic and Diastolic Performance
Section snippets
Participants
The study participants consisted of 24 age-matched healthy control subjects (63 ± 12 years) (group 1), 24 patients with COPD without PH (65 ± 8 years) (group 2), and 20 patients with COPD with PH (64 ± 9 years) (group 3). The control subjects had no cardiovascular or any other systems disease, and had normal physical examination, chest roentgenogram, electrocardiogram, and 2-dimensional and Doppler echocardiogram. The diagnosis of COPD was based on the criteria of the American Thoracic Society.
Clinical Characteristics of the Groups
Clinical characteristics and respiratory parameters of the study population are shown in Table 1. Age, sex, and systemic arterial blood pressures and pH did not differ among the groups. Heart rate and PASP were higher for group 3 than groups 2 and 1, and were higher for group 2 than group 1. FEV1 was lower for group 3 than groups 2 and 1, and was lower for group 2 than group 1. Partial pressure of carbon dioxide was higher, and partial pressure of oxygen was lower for group 3 than group 2.
LV Functions
Discussion
Although LV diastolic dysfunction has been shown in patients with COPD, this is the first study in the literature that evaluated LVMPI as a marker of both systolic and diastolic LV functions in this patient group. Our findings suggest the following: (1) both LV systolic and diastolic functions are impaired in the patients with COPD, especially in those with PH; and (2) these impairments are independently associated with PASP, FEV1, and RVMPI.
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