Original articles—alimentary tractEpidemiology of Eosinophilic Esophagitis Over Three Decades in Olmsted County, Minnesota
Section snippets
Methods
This study was approved by the Mayo Clinic and Olmsted Medical Center Institutional Review Boards. This was a retrospective cohort study.
Case Identification
Figure 1 describes the process of identification of 78 patients with EE. Twenty-three of 78 (29%) of patients with EE were children (patients less than 18 years old at diagnosis).
Validation of Case Identification
Review of the random sample of 100 subjects with a diagnosis of “esophageal ring” who had undergone endoscopy identified 2 subjects with esophagitis and/or eosinophils mentioned in the pathology reports. These cases had already been reviewed by the pathologist as described above (and confirmed not to meet inclusion
Discussion
In this population-based study from the United States, we report secular trends in the epidemiology of eosinophilic esophagitis over the last 3 decades using robust case identification techniques as well a single histology standard. We observed a higher incidence of EE than that reported by previous studies. We found that the incidence of documented EE appears to have increased significantly over the last 3 decades. This increase has however paralleled the increase in endoscopy volume over the
Acknowledgments
The authors thank Judy Peterson for assistance in the data collection and preparation of the manuscript.
References (37)
- et al.
Eosinophilic esophagitis in adults: an emerging problem with unique esophageal features
Gastrointest Endosc
(2004) - et al.
Eosinophilic esophagitis: a 10-year experience in 381 children
Clin Gastroenterol Hepatol
(2005) - et al.
Eosinophilic esophagitis: asthma of the esophagus?
Clin Gastroenterol Hepatol
(2004) - et al.
Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years
Gastroenterology
(2003) - et al.
The small-caliber esophagus: an unappreciated cause of dysphagia for solids in patients with eosinophilic esophagitis
Gastrointest Endosc
(2002) - et al.
Association of eosinophilic inflammation with esophageal food impaction in adults
Gastrointest Endosc
(2005) - et al.
Topical corticosteroid treatment of dysphagia due to eosinophilic esophagitis in adults
Mayo Clin Proc
(2003) - et al.
A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis
Gastroenterology
(2006) - et al.
An audit of endoscopic complications in adult eosinophilic esophagitis
Clin Gastroenterol Hepatol
(2007) - et al.
Eosinophilic esophagitis: escalating epidemiology?
J Allergy Clin Immunol
(2005)
Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment
Gastroenterology
History of the Rochester Epidemiology Project
Mayo Clin Proc
Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment sponsored by the American Gastroenterological Association (AGA) Institute and North American Society of Pediatric Gastroenterology, Hepatology, and Nutrition
Gastroenterology
Epicutaneous antigen exposure primes for experimental eosinophilic esophagitis in mice
Gastroenterology
Intratracheal IL-13 induces eosinophilic esophagitis by an IL-5, eotaxin-1, and STAT6-dependent mechanism
Gastroenterology
Pollen and eosinophilic esophagitis
J Allergy Clin Immunol
Eosinophilic esophagitis in children: immunopathological analysis and response to fluticasone propionate
Gastroenterology
Pediatric patients with eosinophilic esophagitis: an 8-year follow-up
J Allergy Clin Immunol
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Conflict of interest These authors disclose the following: Dr Talley has received research support from Glaxo, Dynogen, and Tioga and has been a consultant to Astra Zeneca, Eisai, and Novartis. Dr Alexander has received research funding from Glaxo and Merck. The remaining authors disclose no conflicts.
Funding Supported in part by Glaxo SmithKline and the National Institutes of Health (U01DK065713-02). This study was also made possible by the Rochester Epidemiology Project (grant R01-AR30582 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases).