Original articles—alimentary tractGenetic Risk Profiling and Prediction of Disease Course in Crohn's Disease Patients
Section snippets
Patient Selection, Study Design, and Data Collection
We reviewed patient files of 970 unrelated IBD patients of Western European origin, recruited in the framework of the IBD genetics study that started in October 1996 until now at the IBD unit of the University Hospital in Leuven, Belgium. The control group consisted of 367 unrelated healthy volunteers without a family history of IBD or other immune-related disorders. Diagnosis of IBD was based on accepted clinical, endoscopic, radiologic, and histologic criteria.17, 18 After thorough review of
Patient Characteristics at Diagnosis and at Last Follow-Up
A total of 755 patients were studied. Patient characteristics are presented in Table 1. At diagnosis, 637 patients (84%) had pure inflammatory disease without strictures, non-perianal or perianal fistulae. During follow-up, 236 of these (37%) developed strictures, 157 (25%) developed non-perianal fistulae, and 177 (28%) developed perianal penetrating disease.
By the time of last follow-up, 253 patients of the total study group (34%) had not developed strictures or non-perianal or perianal
Discussion
Several studies have shown that the implementation of biologic therapies in active refractory CD is associated with mucosal healing and a reduced number of hospitalizations and surgeries.32 This suggests that an early introduction of such therapies might prevent a disabling disease course.33 Therefore, it becomes increasingly desirable to define patients at high risk for such an evolution in an early stage. Previous studies have shown that clinical and demographic markers alone poorly predict
Acknowledgments
The authors thank Vera Ballet for swift administrative assistance and Karolien Claes, Tamara Coopmans, Sophie Organe, and Nele Van Schuerbeek for the excellent technical and scientific support for sample selection, DNA extraction, and genotyping.
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Conflicts of interest The authors disclose no conflicts.
Funding L. Henckaerts is a doctoral fellow and S. Vermeire is a clinical researcher of the Fund for Scientific Research (FWO), Flanders, Belgium. A. Franke was supported by the German Ministry of Education and Research (BMBF) through the National Genome Research Network (NGFN) and received infrastructure support through the DFG excellence cluster “Inflammation at Interfaces.”