Original articleEnvironmental Factors and Colorectal Tumor Risk in Individuals With Hereditary Nonpolyposis Colorectal Cancer
Section snippets
Study Population
Participants for this case-control study on environmental factors and HNPCC-associated colorectal tumors were recruited in the Netherlands between April 1999–April 2002. All participants belonged to a family fulfilling the Amsterdam criteria for HNPCC20, 21 and were known or suspected carriers of a germline mutation in one of the MMR genes. (Amsterdam criteria: at least 3 relatives with colorectal cancer [Amsterdam criteria I] or another HNPCC-associated cancer [ie, endometrial, stomach, ovary,
Results
Characteristics of the study population are presented in Table 1. In total, the study population consisted of 73 known carriers (hMLH1, 49 [67%]; hMSH2, 22 [30%]; gene not disclosed to us, 2 [3%]). The frequency of known carriers did not differ significantly between cases and controls. Of the cases with unknown carrier status (n = 100), 26 (26%) had been diagnosed with at least one adenomatous polyp before 40 years of age, and 14 (14%) had been diagnosed with colorectal cancer before 50 years
Discussion
In this study, we evaluated associations between various environmental factors reported previously to be associated with sporadic colorectal cancer risk and the occurrence of colorectal tumors in known or suspected carriers of a germline mutation in one of the MMR genes. As anticipated, age at last colonoscopy was strongly, positively associated with ever been diagnosed with colorectal tumors in our study population. Fruit consumption lowered the risk of ever developing HNPCC-associated
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Cited by (0)
Supported by the Dutch Cancer Society (grant LUW 98-1687).
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Dr Diergaarde is currently affiliated with the Fred Hutchinson Cancer Research Center, Seattle, Washington.