Original articleThe Effects of Dietary Fat and Calorie Density on Esophageal Acid Exposure and Reflux Symptoms
Section snippets
Subjects
Patients with typical reflux symptoms referred for Bravo pH monitoring were invited to participate in the study. Exclusion criteria included previous upper-gastrointestinal surgery (or interventions), gastrointestinal symptoms other than reflux, ingestion of medication that affects either gastrointestinal function (acid suppression was stopped 4 days before the study), special dietary requirements (eg, diabetes) or behavior (eg, vegetarian), and pregnancy. Subjects provided written informed
Study Progress
Forty-six patients with reflux symptoms waiting for Bravo pH monitoring were contacted between May and September 2005, 22 patients accepted an invitation for screening. One patient was excluded because of dietary restrictions and 2 patients withdrew consent before the study began. Endoscopy was performed in 19 patients, 4 had mild erosive esophagitis and 2 had a small hiatus hernia (acid suppression was stopped only 4 days before the study began). The Bravo capsule failed to deploy in 1 patient
Discussion
Prolonged pH recordings by wireless ambulatory pH measurements provided novel information about the effects of diet in patients with GERD, both in terms of objective esophageal acid exposure and subjective reflux symptoms. This study also provided information about the effects of food consistency on gastroesophageal reflux. The protocol allowed the effects of calorie density, percentage fat content, and food consistency on GERD to be assessed independently. Other factors that may have effects
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Supported by the Guy’s and St. Thomas’ Charitable Trust.