Cancer Cell
Volume 17, Issue 6, 15 June 2010, Pages 584-596
ArticlePhysiological Jak2V617F Expression Causes a Lethal Myeloproliferative Neoplasm with Differential Effects on Hematopoietic Stem and Progenitor Cells
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Highlights
► Preclinical murine model of human PV in which MPN is serially transplantable ► Distinct cell populations responsible for disease initiation and MPN phenotype ► No significant selective competitive advantage for Jak2V617F-expressing HSCs ► Treatment with a JAK2 inhibitor did not eradicate MPN-initiating population
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These authors contributed equally to this work
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